Interaction of MSC with tumor cells.
Interaction of MSC with tumor cells.
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DOI：
10.1186/s12964-016-0143-0
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发表时间：
2016-09-08
期刊：
影响因子：
--
通讯作者：
Hass R
中科院分区：
文献类型：
--
作者：
Melzer C;Yang Y;Hass R
肿瘤的发生和进展不仅取决于相应的肿瘤细胞，还取决于肿瘤微环境。这包括通过细胞外基质和可溶性因子（如细胞因子、趋化因子、生长因子和各种代谢物）相互作用的细胞类型（如免疫细胞、内皮细胞、成纤维细胞和间充质基质/干细胞（MSC））的协调网络。肿瘤微环境的细胞群可以通过相互改变相关伙伴的特性和功能，直接或间接地与癌细胞相互作用。特别是，间充质间质/干细胞（MSC）在癌症发生过程中发挥重要作用，表现出不同类型的细胞间通讯。因此，本研究的重点是MSC与癌细胞相互作用的多种机制。此外，本文还总结了两种细胞类型的一些功能变化和后果，这些变化最终可能导致癌干细胞生态位（CSCN）的建立或通过msc -肿瘤细胞融合产生新的肿瘤细胞群。
Tumor development and tumor progression is not only determined by the corresponding tumor cells but also by the tumor microenvironment. This includes an orchestrated network of interacting cell types (e.g. immune cells, endothelial cells, fibroblasts, and mesenchymal stroma/stem cells (MSC)) via the extracellular matrix and soluble factors such as cytokines, chemokines, growth factors and various metabolites. Cell populations of the tumor microenvironment can interact directly and indirectly with cancer cells by mutually altering properties and functions of the involved partners. Particularly, mesenchymal stroma/stem cells (MSC) play an important role during carcinogenesis exhibiting different types of intercellular communication. Accordingly, this work focusses on diverse mechanisms of interaction between MSC and cancer cells. Moreover, some functional changes and consequences for both cell types are summarized which can eventually result in the establishment of a carcinoma stem cell niche (CSCN) or the generation of new tumor cell populations by MSC-tumor cell fusion.
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