Objective quantification of neuromotor symptoms in Parkinson's disease: implementation of a portable, computerized measurement tool.
Objective quantification of neuromotor symptoms in Parkinson's disease: implementation of a portable, computerized measurement tool.
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DOI：
10.4061/2010/760196
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发表时间：
2010-06-30
期刊：
影响因子：
--
通讯作者：
Levin BE
中科院分区：
文献类型：
--
作者：
Papapetropoulos S;Katzen HL;Scanlon BK;Guevara A;Singer C;Levin BE
使用基于器械的措施对神经运动症状进行量化，为临床评价提供了有用的补充。使用CATALYST的研究已经建立了其作为计算机化测量系统的实用性，以量化神经运动功能。本研究的主要目的是为帕金森病（PD）患者使用CATALYST提供技术指导。前瞻性招募了44例特发性PD患者和28例健康对照，并使用CATALYST（一种基于Windows的便携式系统，由数据记录器和4种不同的传感器（震颤笔、触摸记录板、反应时间手柄和用于平衡记录的测力板）组成）进行评估，以量化神经运动功能。CATEGORY区分PD和控制的测量休息/姿势震颤，旋前/旋后，手指轻敲，简单的反应时间，姿势摇摆强度和速度。使用所提出的测试组合进行的CATALYST测量与评估震颤和运动迟缓的相关临床医师评定的统一帕金森病评定量表（UNITED Parkinson's disease rating scale，UNITED RS）项目相关。有必要开展更多的工作，以建立CATTON作为一个诊断/监测工具，在运动障碍使用拟议的技术方法。
Quantification of neuromotor symptoms with device-based measures provides a useful supplement to clinical evaluation. Research using the CATSYS has established its utility as a computerized measurement system to quantify neuromotor function. The primary objective of this study is to provide technical guidance on the use of the CATSYS in Parkinson's disease (PD). Forty-four patients with idiopathic PD and 28 healthy controls were prospectively recruited and evaluated with CATSYS, a portable, Windows-based system consisting of a data logger and four different sensors (tremor pen, touch recording plate, reaction time handle, and force plate for balance recording) for quantification of neuromotor functions. CATSYS discriminated between PD and controls on measurements of rest/postural tremor, pronation/supination, finger tapping, simple reaction time, and postural sway intensity and velocity. CATSYS measurements using the proposed test battery were associated with relevant clinician-rated Unified Parkinson's disease rating scale (UPDRS) items assessing tremor and bradykinesia. More work is warranted to establish CATSYS as a diagnostic/monitoring instrument in movement disorders using the proposed technical approaches.
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