Dysprosium-Modified Gold Nanoparticles as T2ex Contrast Agents for Magnetic Resonance Imaging
Dysprosium-Modified Gold Nanoparticles as T2ex Contrast Agents for Magnetic Resonance Imaging
复制标题
镝修饰金纳米粒子作为磁共振成像 T2ex 造影剂
DOI：
10.1021/acsanm.0c02044
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发表时间：
2020-08
影响因子：
5.9
通讯作者：
Liu Kai
中科院分区：
文献类型：
--
作者：
Wan Sikang;Cui Fengzhi;Li Bo;Zhao Kelu;He Haonan;Zhang Yi;Liu Jianhua;Zhang Lei;Liu Kai
随着磁共振成像（MRI）技术在高磁场强度领域的发展，需要开发出具有高松弛效果的MRI造影剂。与典型的t1造影剂相比，t2基造影剂的横向弛豫速率随着磁场强度的增加而增加。然而，需要更好的造影剂来改善信噪比问题。本文设计了一系列由金纳米颗粒（NP）和镝配合物（AuNP-DyDOTA(amide)x）组成的2 - 2造影剂。研究了具有不同侧臂链的三种分子的横向弛豫度。经核磁共振信号筛选，AuNP-DyDOTA(amide)2的横向弛豫度为22.9 mM-1s-1at 9.4 T，高于镝基小分子。他们的体内实验结果表明，AuNP-DyDOTA(amide)2在肿瘤区域的特异性积累非常有效，并且实现了快速代谢，这使得它们在未来的超高场强成像和临床诊断中具有前景。
With the development of high magnetic field strength in magnetic resonance imaging (MRI), there is a demand to develop MRI contrast agents to attain high relaxation effects. Compared to typicalT1agents, the transverse relaxation rate ofT2-based contrast agents increases with increasing magnetic field strength. However, better contrast agents are needed to improve the signal-to-noise issue. Here, a series ofT2excontrast agents composed of an Au nanoparticle (NP) and a dysprosium complex (AuNP-DyDOTA(amide)x) were designed. The transverse relaxivity of three molecules bearing different side arm chains were investigated. After screening by NMR signals, the transverse relaxivity of AuNP-DyDOTA(amide)2achieved 22.9 mM–1s–1at 9.4 T, which is higher than dysprosium-based small molecules. Thein vivoresults demonstrate that the AuNP-DyDOTA(amide)2is very efficient for specific accumulation in tumor regions and rapid metabolization was realized, making them promising for ultrahigh field strength imaging and clinical diagnosis in the future.
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影响因子：
62.1
作者：
Wahsner J;Gale EM;Rodríguez-Rodríguez A;Caravan P
通讯作者：
Caravan P
影响因子：
10.8
作者：
Holbrook, Robert J.;Rammohan, Nikhil;Rotz, Matthew W.;MacRenaris, Keith W.;Preslar, Adam T.;Meade, Thomas J.
通讯作者：
Meade, Thomas J.
影响因子：
17.1
作者：
Hu H;Zhang Y;Shukla S;Gu Y;Yu X;Steinmetz NF
通讯作者：
Steinmetz NF
影响因子：
7.8
作者：
Sherry, A. Dean;Wu, Yunkou
通讯作者：
Wu, Yunkou
DOI：
10.1016/j.jconrel.2014.07.038
发表时间：
2014-10-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Ayala-Orozco C;Urban C;Bishnoi S;Urban A;Charron H;Mitchell T;Shea M;Nanda S;Schiff R;Halas N;Joshi A
通讯作者：
Joshi A