Autism-Related Variation in Reciprocal Social Behavior: A Longitudinal Study.

Autism-Related Variation in Reciprocal Social Behavior: A Longitudinal Study.
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DOI:
10.1111/cdev.13170
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发表时间:
2019-03
期刊:
影响因子:
4.6
通讯作者:
Constantino JN
Constantino JN
中科院分区:
心理学1区
文献类型:
--
作者:
Wagner RE;Zhang Y;Gray T;Abbacchi A;Cormier D;Todorov A;Constantino JN

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互惠社会行为的缺陷是自闭症谱系障碍(ASD)的一个特征。在一般人群中,与自闭症相关的互惠社会行为(AVR)变异是连续分布的,并且具有高度遗传性-这是一种加性遗传影响的函数,与产生临床自闭症综合征的遗传影响基本重叠。这是第一项关于儿童期至成年早期AVR稳定性的长期前瞻性研究,在一项涉及ASD儿童、其他精神疾病及其兄弟姐妹(N = 602,年龄= 2.5-29)的队列序贯研究中,使用社会反应量表通过系列评级进行。AVR表现出显着的稳定性,在整个儿童期的个体与ASD。
Deficits in reciprocal social behavior are a characterizing feature of autism spectrum disorder (ASD). Autism‐related variation in reciprocal social behavior (AVR) in the general population is continuously distributed and highly heritable—a function of additive genetic influences that overlap substantially with those which engender clinical autistic syndromes. This is the first long‐term prospective study of the stability of AVR from childhood through early adulthood, conducted via serial ratings using the Social Responsiveness Scale, in a cohort‐sequential study involving children with ASD, other psychiatric conditions, and their siblings (N = 602, ages = 2.5–29). AVR exhibits marked stability throughout childhood in individuals with and without ASD.
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