Gestational and childhood exposure to phthalates and child behavior.
Gestational and childhood exposure to phthalates and child behavior.
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DOI：
10.1016/j.envint.2020.106036
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发表时间：
2020-11
影响因子：
11.8
通讯作者：
Braun JM
中科院分区：
文献类型：
--
作者：
Li N;Papandonatos GD;Calafat AM;Yolton K;Lanphear BP;Chen A;Braun JM
生命早期接触邻苯二甲酸盐可能会破坏甲状腺激素稳态、改变脑脂质代谢或降低性腺激素浓度，从而对神经发育产生不利影响。先前研究妊娠期邻苯二甲酸盐暴露和儿童行为的文献尚无定论，而且很少有前瞻性研究检查儿童期邻苯二甲酸盐暴露，特别是邻苯二甲酸盐混合物。我们调查了妊娠期和儿童期邻苯二甲酸盐暴露是否与儿童行为相关。我们在 HOME 研究中使用了 314 对母子的数据，这是一项纵向怀孕和出生队列，招募了来自俄亥俄州辛辛那提的孕妇。我们对女性在妊娠期间采集的样本进行了两次，并在其孩子 1、2、3、4、5 和 8 岁时采集了 6 次样本，对尿液中 11 种邻苯二甲酸酯代谢物的浓度进行了定量。我们使用儿童行为评估系统 2 评估了 2、3、4、5 和 8 岁时儿童的行为。使用线性混合模型，我们估计了测量误差校正后的妊娠期和儿童期邻苯二甲酸酯代谢物浓度（每四分位数范围增加）与重复儿童行为评估的协变量调整关联。我们使用加权分位数和 (WQS) 回归来估计邻苯二甲酸盐混合物与儿童行为的关联。妊娠期邻苯二甲酸单（3-羧丙酯）（MCPP）浓度与更多问题行为相关（内化：β=0.9，95%置信区间[CI]=−0.1，1.9；外化：β= 1.0，95%CI=−0.1，2.0；行为症状指数[BSI]：β= 1.1，95%CI=0.1，2.1）。高级儿童邻苯二甲酸单苄酯 (MBzP) (β=1.4; 95%CI=0.0, 2.7)、邻苯二甲酸单羧壬酯 (MCNP) (β=3.2; 95%CI=1.6, 4.8)、邻苯二甲酸单羧辛酯 (MCOP) (β=0.9; 95%CI=0.0, 1.7)、MCPP (β=1.8; 95%CI=0.2, 3.5) 和邻苯二甲酸单乙酯 (MEP) (β=1.6; 95%CI=0.1, 3.1) 浓度与较高的 BSI 综合评分相关。与此一致，加权儿童邻苯二甲酸盐指数与更多问题行为相关（内化：β= 1.5，95%CI=−0.2，3.1；外化：β=1.7，95%CI=0.1，3.5；BSI：β= 1.7，95%CI=0.2，3.2）； MBzP、MCNP 和 MEP 对这些协会做出了很大贡献。我们的研究结果表明，儿童时期接触邻苯二甲酸酯混合物可能与儿童的问题行为有关。
Early-life phthalate exposures may adversely influence neurodevelopment by disrupting thyroid hormone homeostasis, altering brain lipid metabolism, or reducing gonadal hormone concentrations. Previous literature examining gestational phthalate exposure and child behavior were inconclusive and few prospective studies have examined childhood phthalate exposure, particularly phthalate mixtures. We investigated whether gestational and childhood phthalate exposures were associated with child behavior. We used data from 314 mother-child pairs in the HOME Study, a longitudinal pregnancy and birth cohort that enrolled pregnant women from Cincinnati, Ohio. We quantified urinary concentrations of 11 phthalate metabolites in samples collected twice during gestation from women and six times from their children when they were ages 1,2,3, 4, 5, and 8 years. We assessed children’s behavior at ages 2, 3, 4, 5, and 8 years using the Behavioral Assessment System for Children-2. Using linear mixed models, we estimated covariate-adjusted associations of measurement-error-corrected gestational and childhood phthalate metabolite concentrations (per interquartile range increase) with repeated child behavior assessments. We used Weighted Quantile Sum (WQS) regression to estimate the association of phthalate mixtures with child behavior. Gestational mono(3-carboxypropyl) phthalate (MCPP) concentrations were associated with more problem behaviors (internalizing: β=0.9, 95% confidence interval [CI]=−0.1, 1.9; externalizing: β= 1.0, 95%CI=−0.1, 2.0; behavioral symptoms index [BSI]: β= 1.1, 95%CI=0.1, 2.1). Higher childhood monobenzyl phthalate (MBzP) (β=1.4; 95%CI=0.0, 2.7), monocarboxynonyl phthalate (MCNP) (β=3.2; 95%CI=1.6, 4.8), monocarboxyoctyl phthalate (MCOP) (β=0.9; 95%CI=0.0, 1.7), MCPP (β=1.8; 95%CI=0.2, 3.5), and monoethyl phthalate (MEP) (β=1.6; 95%CI=0.1, 3.1) concentrations were associated with higher BSI composite scores. Consistent with this, the weighted childhood phthalate index was associated with more problem behaviors (internalizing: β= 1.5, 95%CI=−0.2, 3.1; externalizing: β=1.7, 95%CI=0.1, 3.5; BSI: β= 1.7, 95%CI=0.2, 3.2); MBzP, MCNP, and MEP largely contributed to these associations. Our findings suggest that childhood exposure to phthalate mixtures may be associated with children’s problem behaviors.
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影响因子：
8.3
作者：
Doherty, Brett T.;Engel, Stephanie M.;Buckley, Jessie P.;Silva, Manori J.;Calafat, Antonia M.;Wolff, Mary S.
通讯作者：
Wolff, Mary S.
影响因子：
10.4
作者：
Bornehag, Carl-Gustaf;Lundgren, Bjorn;Weschler, Charles J;Sigsgaard, Torben;Hagerhed-Engman, Linda;Sundell, Jan
通讯作者：
Sundell, Jan
影响因子：
3.6
作者：
Braun JM;Sathyanarayana S;Hauser R
通讯作者：
Hauser R
影响因子：
4.1
作者：
Breous, E;Wenzel, A;Loos, U
通讯作者：
Loos, U
影响因子：
3.3
作者：
Calafat AM
通讯作者：
Calafat AM