Individual Variability in Bothropsatrox Snakes Collected from Different Habitats in the Brazilian Amazon: New Findings on Venom Composition and Functionality.
Individual Variability in Bothropsatrox Snakes Collected from Different Habitats in the Brazilian Amazon: New Findings on Venom Composition and Functionality.
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DOI：
10.3390/toxins13110814
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发表时间：
2021-11-18
期刊：
影响因子：
4.2
通讯作者：
Moura-da-Silva AM
中科院分区：
文献类型：
--
作者：
Sousa LF;Holding ML;Del-Rei THM;Rocha MMT;Mourão RHV;Chalkidis HM;Prezoto B;Gibbs HL;Moura-da-Silva AM
蛇毒成分的差异发生在所有分类学水平上，有人认为这种变化代表了一种适应，这种适应已经进化到便于捕获和消化猎物以及逃避捕食者。Bothrops atrox是一种陆地pitviper，分布在亚马逊地区，在那里它占据了不同的栖息地。使用统计分析和功能测定，结合个体差异，我们分析了个体毒液的变异性在B。在巴西亚马逊河及其周围的四个不同的栖息地（森林，牧场，退化地区和洪泛平原）中发现了一种黑腹蛇。我们观察到空间上不同的B之间的毒液分化。来自不同栖息地的atrox个体，由于常见（高丰度）和罕见（低丰度）蛋白质，毒液变化。此外，毒液组成的差异导致了对哺乳动物和鸟类，特别是河漫滩蛇的致命性的功能和异质性的个体差异。综上所述，从B个体毒液中获得的数据。atrox蛇，在不同的栖息地从巴西亚马逊捕获，支持这一假设的差异分布的蛋白质异构体的结果在功能上的独特性和能力的蛇与不同的毒液对不同的猎物有可变的毒性作用。
Differences in snake venom composition occur across all taxonomic levels and it has been argued that this variation represents an adaptation that has evolved to facilitate the capture and digestion of prey and evasion of predators. Bothrops atrox is a terrestrial pitviper that is distributed across the Amazon region, where it occupies different habitats. Using statistical analyses and functional assays that incorporate individual variation, we analyzed the individual venom variability in B. atrox snakes from four different habitats (forest, pasture, degraded area, and floodplain) in and around the Amazon River in Brazil. We observed venom differentiation between spatially distinct B. atrox individuals from the different habitats, with venom variation due to both common (high abundance) and rare (low abundance) proteins. Moreover, differences in the composition of the venoms resulted in individual variability in functionality and heterogeneity in the lethality to mammals and birds, particularly among the floodplain snakes. Taken together, the data obtained from individual venoms of B. atrox snakes, captured in different habitats from the Brazilian Amazon, support the hypothesis that the differential distribution of protein isoforms results in functional distinctiveness and the ability of snakes with different venoms to have variable toxic effects on different prey.
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影响因子：
4.2
作者：
Freitas-de-Sousa LA;Nachtigall PG;Portes-Junior JA;Holding ML;Nystrom GS;Ellsworth SA;Guimarães NC;Tioyama E;Ortiz F;Silva BR;Kunz TS;Junqueira-de-Azevedo ILM;Grazziotin FG;Rokyta DR;Moura-da-Silva AM
通讯作者：
Moura-da-Silva AM
DOI：
10.1016/j.toxcx.2020.100037
发表时间：
2020-06-01
期刊：
TOXICON-X
影响因子：
--
作者：
Monteiro, Wuelton Marcelo;Contreras-Bernal, Jorge Carlos;Moura-da-Silva, Ana Maria
通讯作者：
Moura-da-Silva, Ana Maria
影响因子：
3.3
作者：
Calvete, Juan J.;Sanz, Libia;Moura-Da-Silva, Ana M.
通讯作者：
Moura-Da-Silva, Ana M.
影响因子：
2.8
作者：
Del-Rei, Tiago H. Moretto;Sousa, Leijiane F.;Moura-da-Silva, Ana M.
通讯作者：
Moura-da-Silva, Ana M.
影响因子：
3.7
作者：
Bernardoni JL;Sousa LF;Wermelinger LS;Lopes AS;Prezoto BC;Serrano SM;Zingali RB;Moura-da-Silva AM
通讯作者：
Moura-da-Silva AM