Marine natural products and their potential applications as anti-infective agents.
Marine natural products and their potential applications as anti-infective agents.
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DOI：
10.1016/s1473-3099(03)00655-8
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发表时间：
2003-06
期刊：
影响因子：
--
通讯作者：
Hamann MT
中科院分区：
文献类型：
--
作者：
Donia M;Hamann MT
海洋是一种独特的资源，提供了各种各样的自然产品，主要来自海绵、被囊动物、苔藓动物和软体动物等无脊椎动物，以及海洋细菌和蓝藻。随着传染病的进化并对现有药物产生抗药性，海洋环境为对抗真菌、寄生虫、细菌和病毒疾病提供了新的线索。许多海洋天然产物已成功进入临床试验的后期阶段，包括多司他丁10、埃克西丁-743、Kahalalide F和阿普利定，越来越多的候选药物被选为扩展临床前评估的有希望的线索。虽然许多海洋产品的临床试验是为了癌症化疗，但耐药性、新出现的传染病和生物恐怖主义的威胁都促使人们对评估天然海洋产品在治疗传染病生物方面的兴趣。在这篇综述中，我们重点介绍了经过药理测试的海洋先导化合物，这些先导化合物在体内显示了抗传染病和寄生虫病的有效性或体外活性。
The oceans are a unique resource that provide a diverse array of natural products, primarily from invertebrates such as sponges, tunicates, bryozoans, and molluscs, and from marine bacteria and cyanobacteria. As infectious diseases evolve and develop resistance to existing pharmaceuticals, the marine environment provides novel leads against fungal, parasitic, bacterial, and viral diseases. Many marine natural products have successfully advanced to the late stages of clinical trials, including dolastatin 10, ecteinascidin-743, kahalalide F, and aplidine, and a growing number of candidates have been selected as promising leads for extended preclinical assessment. Although many marine-product clinical trials are for cancer chemotherapy, drug resistance, emerging infectious diseases, and the threat of bioterrorism have all contributed to the interest in assessing natural ocean products in the treatment of infectious organisms. In this review, we focus on the pharmacologically tested marine leads that have shown in-vivo efficacy or potent in-vitro activity against infectious and parasitic diseases.
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影响因子：
2.1
作者：
Compagnone, RS;Piña, IC;Faulkner, DJ
通讯作者：
Faulkner, DJ
影响因子：
2.1
作者：
Fontana, A;Cavaliere, P;Cimino, G
通讯作者：
Cimino, G
影响因子：
5.1
作者：
Capon, RJ;Skene, C;Friedel, T
通讯作者：
Friedel, T
DOI：
10.1016/s1572-5995(00)80051-4
发表时间：
2000
期刊：
Studies in Natural Products Chemistry
影响因子：
--
作者：
El Sayed KA
通讯作者：
El Sayed KA
影响因子：
2.4
作者：
Friedrich, AB;Merkert, H;Hentschel, U
通讯作者：
Hentschel, U