Drusen morphometrics on optical coherence tomography in eyes with age-related macular degeneration and normal aging.
Drusen morphometrics on optical coherence tomography in eyes with age-related macular degeneration and normal aging.
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DOI：
10.1007/s00417-023-06088-z
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发表时间：
2023-09
影响因子：
2.7
通讯作者：
Sadda, SriniVas R.
中科院分区：
文献类型：
--
作者：
Oncel, Deniz;Corradetti, Giulia;Wakatsuki, Yu;Nittala, Muneeswar Gupta;Velaga, Swetha Bindu;Stambolian, Dwight;Pericak-Vance, Margaret A.;Haines, Jonathan L.;Sadda, SriniVas R.
将光学相干断层扫描 (OCT) B 扫描的玻璃膜疣大小指标（顶端高度和基底宽度）与年龄相关性黄斑变性 (AMD) 和正常衰老眼睛的彩色照片评估的大小进行比较。本次分析共评估了 508 个玻璃疣。对同一次就诊时获得的闪光彩色眼底照片 (CFP)、红外反射 (IR) 图像和 OCT B 扫描进行了评估。在 CFP 上识别单个玻璃疣，并在平面分级软件中测量玻璃疣的直径。 CFP 手动配准到红外图像及其相应的 OCT 体积。确认 CFP 和 OCT 之间的对应关系后，在 OCT B 扫描上测量同一玻璃膜疣的顶端高度和基底宽度。根据 CFP 图像上的直径，玻璃膜疣被分为小型、中型、大型和超大类别（分别为 <63、63 至 124、125 至 249 和≥250 μm）。 CFP上小玻璃膜疣的OCT顶端高度范围为20至31μm，中型玻璃膜疣的范围为31至46μm，大玻璃膜疣的范围为45μm至111μm，非常大的玻璃膜疣的范围为55μm至208μm。小玻璃膜疣的 OCT 基底宽度测量为 < 99 μm，中型玻璃膜疣为 99 至 143 μm，大玻璃膜疣为 141 至 407 μm，非常大玻璃膜疣 >209 μm。彩色照片上不同尺寸类别的玻璃膜疣也可以根据 OCT 上的顶端高度和基底宽度进行区分。本分析中定义的根尖高度和基底宽度范围可能对设计基于 OCT 的 AMD 分级量表有价值。
To compare drusen size metrics (apical height and basal width) on optical coherence tomography (OCT) B-scans with their size assessed on color photos in eyes with age-related macular degeneration (AMD) and normal aging. A total of 508 drusen were evaluated in this analysis. Flash color fundus photos (CFP), infrared reflectance (IR) images, and OCT B-scans obtained at the same visit were evaluated. Individual drusen were identified on CFPs and the diameter of the drusen were measured in planimetric grading software. CFPs were manually registered to the IR image with its corresponding OCT volume. After confirming correspondence between the CFP and OCT, the apical height and basal width of the same drusen were measured on OCT B-scans. Drusen were divided into small, medium, large, and very large categories based on their diameter on the CFP images (<63, 63 to 124, 125 to 249 and ≥250 μm, respectively). The OCT apical height of small drusen on CFP ranged from 20 to 31 μm, while medium drusen ranged from 31 to 46 μm, large drusen ranged from 45 μm to 111 μm, and very large drusen ranged from 55 μm to 208 μm. The OCT basal width measured < 99 μm in small drusen, from 99 to 143 μm in medium drusen, from 141 to 407 μm in large drusen, and >209 μm very large drusen. Drusen of different size categories on color photographs may also be separated according to their apical height and basal width on OCT. The apical height and basal width ranges defined in this analysis may be of value in the design of an OCT-based grading scale for AMD.
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影响因子：
1
作者：
Kuehlewein, Laura;Dustin, Laurie;Sadda, SriniVas R.
通讯作者：
Sadda, SriniVas R.
DOI：
10.1007/s00417-015-3012-4
发表时间：
2016-01-01
影响因子：
2.7
作者：
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通讯作者：
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影响因子：
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DOI：
10.1097/iae.0000000000003099
发表时间：
2021-08-01
影响因子：
3.3
作者：
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通讯作者：
Jaffe, Glenn J.
影响因子：
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作者：
Nittala, Muneeswar G.;Hariri, Amirhossein;Sadda, Srinivas R.
通讯作者：
Sadda, Srinivas R.