New data on the immunocytochemical localization of thyrotropin-releasing hormone in the rat central nervous system.
New data on the immunocytochemical localization of thyrotropin-releasing hormone in the rat central nervous system.
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关于大鼠中枢神经系统促甲状腺素释放激素免疫细胞化学定位的新数据。
DOI：
10.1002/aja.1001810404
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
B. Mess
中科院分区：
文献类型：
--
作者：
I. Merchenthaler;V. Csernus;C. Csontos;P. Petrusz;B. Mess
用抗合成的焦谷氨酰-组氨酰-脯氨酸三肽（游离酸）的抗血清，用免疫细胞化学方法，对大鼠中枢神经系统（CNS）内促甲状腺激素释放激素（TRH）进行了定位。TRH免疫反应性结构的分布与先前报道的相似;即，含TRH的胞体主要位于下丘脑室旁核的小细胞部、视前核的视交叉上部、背内侧核、下丘脑外侧基底核和中缝核。TRH免疫反应阳性神经元的几个新的位置也被观察到，包括球层的嗅球，前嗅核，斜角带的Broca，隔核，性二形核的视前区，丘脑网状核，外侧网状核的延髓，和中央灰质的中脑。免疫反应纤维见于正中隆起、终板血管器、外侧隔核、内侧缰核、臂旁背侧核和臂旁腹侧核、孤束核、脑神经运动核周围、迷走神经背侧复合体和脑干网状结构。在脊髓中，未观察到免疫反应性胞体。免疫反应过程中存在于外侧索的白色物质和在层V-X的灰质。脊髓运动神经元周围可见密集的终末样结构。TRH免疫反应性结构在CNS中的分布表明TRH在下丘脑中既作为神经内分泌调节剂又作为神经递质或神经调质在整个CNS中发挥作用。
An antiserum raised against the synthetic tripeptide pyroglutamyl-histidyl-proline (free acid) was used to localize thyrotropin-releasing hormone (TRH) in the rat central nervous system (CNS) by immunocytochemistry. The distribution of TRH-immunoreactive structures was similar to that reported earlier; i.e., most of the TRH-containing perikarya were located in the parvicellular part of the hypothalamic paraventricular nucleus, the suprachiasmatic portion of the preoptic nucleus, the dorsomedial nucleus, the lateral basal hypothalamus, and the raphe nuclei. Several new locations for TRH-immunoreactive neurons were also observed, including the glomerular layer of the olfactory bulb, the anterior olfactory nuclei, the diagonal band of Broca, the septal nuclei, the sexually dimorphic nucleus of the preoptic area, the reticular thalamic nucleus, the lateral reticular nucleus of the medulla oblongata, and the central gray matter of the mesencephalon. Immunoreactive fibers were seen in the median eminence, the organum vasculosum of the lamina terminalis, the lateral septal nucleus, the medial habenula, the dorsal and ventral parabrachial nuclei, the nucleus of the solitary tract, around the motor nuclei of the cranial nerves, the dorsal vagal complex, and in the reticular formation of the brainstem. In the spinal cord, no immunoreactive perikarya were observed. Immunoreactive processes were present in the lateral funiculus of the white matter and in laminae V-X in the gray matter. Dense terminal-like structures were seen around spinal motor neurons. The distribution of TRH-immunoreactive structures in the CNS suggests that TRH functions both as a neuroendocrine regulator in the hypothalamus and as a neurotransmitter or neuromodulator throughout the CNS.
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七鳃鳗中枢神经系统中的促甲状腺素释放激素。
影响因子：
2.9
作者：
Youngs,LJ;Winokur,A;Selzer,ME
通讯作者：
Selzer,ME
促甲状腺素释放激素前体在大鼠脑中的免疫组织化学定位。
DOI：
10.1126/science.3929378
发表时间：
1985
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jackson,IM;Wu,P;Lechan,RM
通讯作者：
Lechan,RM
影响因子：
56.9
作者：
LECHAN, RM;WU, P;GOODMAN, RH
通讯作者：
GOODMAN, RH
影响因子：
4.8
作者：
R. Lechan;P. Wu;I. Jackson
通讯作者：
R. Lechan;P. Wu;I. Jackson
影响因子：
4.8
作者：
LECHAN, RM;JACKSON, IMD
通讯作者：
JACKSON, IMD