Emerging Biomarkers for Prediction and Early Diagnosis of Necrotizing Enterocolitis in the Era of Metabolomics and Proteomics.
Emerging Biomarkers for Prediction and Early Diagnosis of Necrotizing Enterocolitis in the Era of Metabolomics and Proteomics.
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代谢组学和蛋白质组学时代用于预测和早期诊断坏死性小肠结肠炎的新兴生物标志物。
DOI：
10.3389/fped.2020.602255
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发表时间：
2020
影响因子：
2.6
通讯作者：
Sarafidis K
中科院分区：
文献类型：
--
作者：
Agakidou E;Agakidis C;Gika H;Sarafidis K
坏死性小肠结肠炎（NEC）是一种主要影响早产儿的灾难性疾病，其特点是高死亡率和严重的长期后果。传统上，NEC的诊断是基于临床和影像学表现，然而，这些对NEC是非特异性的，因此混淆了其他疾病的鉴别诊断，如新生儿脓毒症和自发性肠穿孔。此外，当临床和放射学表现变得明显时，NEC已经进展到晚期。在过去的三十年中，大量的研究集中在发现生物标志物上，这些生物标志物可以准确地预测和早期诊断NEC。迄今为止在临床实践中使用的生物标志物包括急性期蛋白、炎症介质和参与免疫反应的分子。然而，没有一种被证明足够准确地预测和早期诊断NEC或区分临床与外科NEC或其他非NEC胃肠道疾病。NEC发病机制的复杂性在很大程度上仍未得到阐明，这可以部分解释现有NEC生物标志物的诊断性能不理想的原因。最近应用的技术可以为NEC的病理生理机制提供重要的见解，但也可以帮助检测潜在的预测性、早期诊断和预后生物标志物。组学技术的进步已经允许同时测量大量蛋白质、代谢产物、脂质和基因，使用血清/血浆、尿液、粪便、组织和其他生物标本。这篇综述更新了目前使用蛋白质组学和代谢组学检测到的新兴NEC生物标志物的数据，进一步讨论了NEC预测和早期诊断的局限性和未来前景。
Necrotizing Enterocolitis (NEC) is a catastrophic disease affecting predominantly premature infants and is characterized by high mortality and serious long-term consequences. Traditionally, diagnosis of NEC is based on clinical and radiological findings, which, however, are non-specific for NEC, thus confusing differential diagnosis of other conditions such as neonatal sepsis and spontaneous intestinal perforation. In addition, by the time clinical and radiological findings become apparent, NEC has already progressed to an advanced stage. During the last three decades, a lot of research has focused on the discovery of biomarkers, which could accurately predict and make an early diagnosis of NEC. Biomarkers used thus far in clinical practice include acute phase proteins, inflammation mediators, and molecules involved in the immune response. However, none has been proven accurate enough to predict and make an early diagnosis of NEC or discriminate clinical from surgical NEC or other non-NEC gastrointestinal diseases. Complexity of mechanisms involved in NEC pathogenesis, which remains largely poorly elucidated, could partly explain the unsatisfactory diagnostic performance of the existing NEC biomarkers. More recently applied technics can provide important insight into the pathophysiological mechanisms underlying NEC but can also aid the detection of potentially predictive, early diagnostic, and prognostic biomarkers. Progress in omics technology has allowed for the simultaneous measurement of a large number of proteins, metabolic products, lipids, and genes, using serum/plasma, urine, feces, tissues, and other biological specimens. This review is an update of current data on emerging NEC biomarkers detected using proteomics and metabolomics, further discussing limitations and future perspectives in prediction and early diagnosis of NEC.
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影响因子：
2.4
作者：
Chaaban, Hala;Markel, Troy A.;Good, Misty
通讯作者：
Good, Misty
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob
DOI：
10.3109/14767058.2010.511335
发表时间：
2011-04-01
影响因子：
1.8
作者：
Cortez, Josef;Gupta, Meenakshi;Sood, Beena G.
通讯作者：
Sood, Beena G.
影响因子：
3.7
作者：
Nguyen DN;Jiang P;Jacobsen S;Sangild PT;Bendixen E;Chatterton DE
通讯作者：
Chatterton DE
影响因子：
--
作者：
Alganabi, Mashriq;Lee, Carol;Pierro, Agostino
通讯作者：
Pierro, Agostino