The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates.
The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates.
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DOI：
10.1016/j.neulet.2010.06.012
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发表时间：
2010-08-16
影响因子：
2.5
通讯作者：
Gorman JM
中科院分区：
文献类型：
--
作者：
Coplan JD;Abdallah CG;Tang CY;Mathew SJ;Martinez J;Hof PR;Smith EL;Dwork AJ;Perera TD;Pantol G;Carpenter D;Rosenblum LA;Shungu DC;Gelernter J;Kaffman A;Jackowski A;Kaufman J;Gorman JM
Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) may be effective in treating depression. Parental verbal abuse has been linked to decreased fractional anisotropy (FA) of white matter and reduced FA correlated with depression and anxiety scores. Utilizing a nonhuman primate model of mood and anxiety disorders following disrupted mother-infant attachment, we examined whether adverse rearing conditions lead to white matter impairment of the ALIC. We examined white matter integrity using Diffusion Tensor Imaging (DTI) on a 3T-MRI. Twenty-one adult male Bonnet macaques participated in this study: 12 were reared under adverse [variable foraging demand (VFD)] conditions whereas 9 were reared under normative conditions. We examined ALIC, posterior limb of the internal capsule (PLIC) and occipital white matter. VFD rearing was associated with significant reductions in FA in the ALIC with no changes evident in the PLIC or occipital cortex white matter. Adverse rearing in monkeys persistently impaired frontal white matter tract integrity, a novel substrate for understanding affective susceptibility.
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影响因子：
10.6
作者：
Gutman, David A.;Holtzheimer, Paul E.;Behrens, Timothy E. J.;Johansen-Berg, Heidi;Mayberg, Helen S.
通讯作者：
Mayberg, Helen S.
影响因子：
2.5
作者：
de Souza Duran, Fabio Luis;Hoexter, Marcelo Queiroz;Busatto, Geraldo Filho
通讯作者：
Busatto, Geraldo Filho
影响因子：
7.4
作者：
Cannistraro, Paul A.;Makris, Nikos;Rauch, Scott L.
通讯作者：
Rauch, Scott L.
DOI：
10.1073/pnas.93.4.1619
发表时间：
1996-02-20
影响因子：
11.1
作者：
Coplan, JD;Andrews, MW;Nemeroff, CB
通讯作者：
Nemeroff, CB
影响因子：
10.6
作者：
ROSENBLUM, LA;COPLAN, JD;ANDREWS, MW
通讯作者：
ANDREWS, MW