Evaluation of Quantified Social Perception Circuit Activity as a Neurobiological Marker of Autism Spectrum Disorder.
Evaluation of Quantified Social Perception Circuit Activity as a Neurobiological Marker of Autism Spectrum Disorder.
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评估量化的社会感知电路活动是自闭症谱系障碍的神经生物学标志物。
DOI：
10.1001/jamapsychiatry.2016.0219
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发表时间：
2016-06-01
期刊：
影响因子：
25.8
通讯作者：
Kaiser MD
中科院分区：
文献类型：
--
作者：
Björnsdotter M;Wang N;Pelphrey K;Kaiser MD
自闭症谱系障碍（ASD）以社交障碍为特征，与支持社交线索感知的脑回路功能障碍有关。神经功能在多大程度上反映了个体水平的行为表型尚不清楚，减缓了对ASD功能性神经影像学生物标志物的研究。研究社会感知回路中量化的神经功能是否可以作为儿童和青少年ASD的个体水平标记。这项队列研究在耶鲁儿童研究中心进行，涉及被诊断为ASD的儿童和青少年以及典型的发育参与者。参与者包括一个发现队列和一个更大的复制队列。个体水平的社会知觉回路功能被评估为功能性磁共振成像大脑对相干与杂乱的人类运动的点光显示的反应。结果测量包括受影响男性和女性参与者的量化脑反应的表现，包括受试者工作特征曲线（AUC）下的面积，灵敏度和特异性，以及脑反应与社会行为之间的相关性。在年龄在4 - 17岁的39名参与者中，22名患有ASD，30名为男孩。在75名7至20岁的重复队列参与者中，37名患有ASD，52名为男孩。在发现队列中，ASD男孩的社会感知回路反应相对减少，AUC为0.75（95% CI，0.52-0.89; P = 0.01）;然而，通常发育中的女孩和ASD女孩无法区分（P = 0.54）。结果在重复队列中得到证实，其中在ASD男孩中确定了脑反应，AUC为0.79（95%CI，0.64-0.91; P < .001），并且未能区分受影响和未受影响的女孩（P = .82）。在两个队列中，男孩的AUC为0.77（95% CI，0.64-0.86），相应的灵敏度和特异性均为76%。此外，男孩的大脑反应与社会行为有关，但女孩则不然。量化的社会知觉回路活动是一个有前途的个体水平的候选神经标记的男性ASD行为表型。我们的研究结果强调需要更好地了解性别对ASD表型表现相关的社会感知处理的影响。
Autism spectrum disorder (ASD) is marked by social disability and is associated with dysfunction in brain circuits supporting social cue perception. The degree to which neural functioning reflects individual-level behavioral phenotype is unclear, slowing the search for functional neuroimaging biomarkers of ASD. To examine whether quantified neural function in social perception circuits may serve as an individual-level marker of ASD in children and adolescents. The cohort study was conducted at the Yale Child Study Center and involved children and adolescents diagnosed as having ASD and typically developing participants. Participants included a discovery cohort and a larger replication cohort. Individual-level social perception circuit functioning was assessed as functional magnetic resonance imaging brain responses to point-light displays of coherent vs scrambled human motion. Outcome measures included performance of quantified brain responses in affected male and female participants in terms of area under the receiver operating characteristic curve (AUC), sensitivity and specificity, and correlations between brain responses and social behavior. Of the 39 participants in the discovery cohort aged 4to 17 years, 22 had ASD and 30 were boys. Of the 75 participants in the replication cohort aged 7 to 20 years, 37 had ASD and 52 were boys. A relative reduction in social perception circuit responses was identified in discovery cohort boys with ASD at an AUC of 0.75 (95% CI, 0.52–0.89; P = .01); however, typically developing girls and girls with ASD could not be distinguished (P = .54). The results were confirmed in the replication cohort, where brain responses were identified in boys with ASD at an AUC of 0.79 (95% CI, 0.64–0.91; P < .001) and failed to distinguish affected and unaffected girls (P = .82). Across both cohorts, boys were identified at an AUC of 0.77 (95% CI, 0.64–0.86) with corresponding sensitivity and specificity of 76% each. Additionally, brain responses were associated with social behavior in boys but not in girls. Quantified social perception circuit activity is a promising individual-level candidate neural marker of the male ASD behavioral phenotype. Our findings highlight the need to better understand effects of sex on social perception processing in relation to ASD phenotype manifestations.
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影响因子：
3.7
作者：
Koldewyn K;Whitney D;Rivera SM
通讯作者：
Rivera SM
DOI：
10.1073/pnas.1312857110
发表时间：
2013-12-24
影响因子：
11.1
作者：
Gordon, Ilanit;Vander Wyk, Brent C.;Pelphrey, Kevin A.
通讯作者：
Pelphrey, Kevin A.
DOI：
10.1016/j.cub.2011.12.056
发表时间：
2012-02-21
期刊：
Current biology : CB
影响因子：
--
作者：
Elsabbagh M;Mercure E;Hudry K;Chandler S;Pasco G;Charman T;Pickles A;Baron-Cohen S;Bolton P;Johnson MH;BASIS Team
通讯作者：
BASIS Team
影响因子：
2.5
作者：
Ahmed, Alex A.;Vander Wyk, Brent C.
通讯作者：
Vander Wyk, Brent C.
影响因子：
4.8
作者：
Goebel, R;Esposito, F;Formisano, E
通讯作者：
Formisano, E