Lifestyle interaction with fat mass and obesity-associated (FTO) genotype and risk of obesity in apparently healthy U.S. women.
Lifestyle interaction with fat mass and obesity-associated (FTO) genotype and risk of obesity in apparently healthy U.S. women.
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DOI：
10.2337/dc10-0948
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发表时间：
2011-03
期刊：
影响因子：
16.2
通讯作者：
Mora S
中科院分区：
文献类型：
--
作者：
Ahmad T;Lee IM;Paré G;Chasman DI;Rose L;Ridker PM;Mora S
脂肪量和肥胖相关（FTO）基因的变异与肥胖有关。体力活动和热量摄入的单独和联合作用在多大程度上改变了这种关联仍不清楚。在21，675名表面健康的高加索女性中，测量了FTO多态性rs 8050136，并自我报告了体力活动，热量摄入和人体测量。风险等位基因（A）对BMI的影响在不活动或高摄入量的女性中更大，不活动和高摄入量对相关遗传风险具有累加效应。具体而言，每个A等位基因与非活动女性（≤中位数，8.8 MET小时/周）的平均BMI差异+0.73（SE 0.08）kg/m2相关，而与活动女性（>8.8 MET小时/周）的平均BMI差异+0.31（0.06）kg/m2相关，P < 0.0001。同样，每个A等位基因与高摄入量女性（>中位数，1，679千卡/天）的平均BMI差异+0.65（0.07）相关，而与低摄入量女性（≤ 1，679千卡/天）的平均BMI差异+0.38（0.07）kg/m2相关，P = 0.005。在不活动/高摄入量女性中，每个A等位基因与平均BMI差异相关，分别为+0.97（0.11）kg/m2和+0.22（0.08）kg/m2，P < 0.0001。在不活动/高摄入量的女性中，每个A等位基因携带肥胖（比值比1.39，95% CI 1.27-1.52）和糖尿病（比值比1.36，95% CI 1.07-1.73）的风险增加。在这项研究中，生活方式因素改变了FTO对肥胖表型的遗传风险，特别是在不活动和高摄入量的女性中。更健康的生活方式会减弱，但并不能完全消除相关的遗传风险。
Variation in the fat mass and obesity-associated (FTO) gene is associated with obesity. The extent to which separate and combined effects of physical activity and caloric intake modify this association remains unclear. FTO polymorphism rs8050136 was measured, and physical activity, caloric intake, and anthropometrics were self-reported in 21,675 apparently healthy Caucasian women. The effect of the risk allele (A) on BMI was larger among inactive or higher intake women, with additive effects of inactivity and high intake on the associated genetic risk. Specifically, each A allele was associated with mean BMI difference of +0.73 (SE 0.08) kg/m2 among inactive women (≤median, 8.8 MET-hours/week), compared with +0.31 (0.06) kg/m2, P < 0.0001, among active women (>8.8 MET-hours/week). Similarly, each A allele was associated with mean BMI difference of +0.65 (0.07) among high intake women (>median, 1,679 kcals/day), compared with +0.38 (0.07) kg/m2, P = 0.005, among low intake women (≤1,679 kcals/day). Among inactive/high intake women, each A allele was associated with mean BMI difference of +0.97 (0.11) kg/m2 vs. +0.22 (0.08) kg/m2 among inactive/low intake women, P < 0.0001. Among inactive/high intake women, each A allele carried increased risk of obesity (odds ratio 1.39, 95% CI 1.27–1.52) and diabetes (odds ratio 1.36, 95% CI 1.07–1.73). In this study, lifestyle factors modified the genetic risk of FTO on obesity phenotypes, particularly among women who were both inactive and had high intake. Healthier lifestyle patterns blunted but did not completely eliminate the associated genetic risk.
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影响因子：
158.5
作者：
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通讯作者：
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通讯作者：
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作者：
WILLETT, WC;SAMPSON, L;SPEIZER, FE
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SPEIZER, FE