Effects of Origanum majorana on Breast Cancer Cells: An Alternative to Chemotherapy?
Effects of Origanum majorana on Breast Cancer Cells: An Alternative to Chemotherapy?
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DOI：
10.3390/metabo13101083
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发表时间：
2023-10-16
期刊：
影响因子：
4.1
通讯作者：
Ivankovic D
中科院分区：
文献类型：
--
作者：
Sanders Z;Moffitt BA;Treaster M;Larkins A;Khulordava N;Benjock J;Spencer J;Henrie K;Wurst MJ;Broom A;Tamez N;DeRosa G;Campbell M;Keller E;Powell A;Weinbrenner D;Abenavoli L;Edenfield WJ;Chung K;Boccuto L;Ivankovic D
最近的研究报告了天然化合物对癌细胞的几种有益作用，强调了它们在未来治疗中的用途。这些初步发现鼓励对天然物质进行实验，如植物提取物，以检查细胞毒性和有丝分裂效应，并找到乳腺癌等疾病的替代治疗方法。本研究探讨了马钱子的微波辅助和乙醇浸泡对MCF-7乳腺癌细胞株和正常乳腺组织细胞系的影响。在MTS试验中，马钱子提取物对MCF-7细胞有细胞毒作用，对对照细胞有促有丝分裂作用。使用Biolog表型哺乳动物代谢(PM-M)平台对MCF-7和对照细胞系的代谢谱进行了评估，发现在能源利用、某些离子物种存在的代谢活性以及对代谢效应物质(如刺激剂/分解代谢化合物和类固醇激素)的反应方面存在统计学上的显著差异。马霍兰提取物对MCF-7细胞的能量异常利用和对代谢效应物的反应有积极作用，而对对照细胞无明显影响。这些作用与化疗药物阿霉素的代谢影响进行了比较，阿霉素对癌细胞和正常乳腺细胞都显示了深刻的细胞毒作用。总之，我们的体外证据表明，马乔兰提取物是乳腺癌化疗的一种有前途的替代方案，因为它们可以通过影响癌细胞的代谢能力增殖而成功地消除癌细胞，而不会对正常的乳腺组织产生明显的不良影响。
Recent studies have reported several beneficial effects of natural compounds on cancerous cells, highlighting their use for future treatments. These preliminary findings have encouraged experiments with natural substances, such as plant extracts, to examine both cytotoxic and mitogenic effects and find alternative treatments for diseases such as breast cancer. This study examines the effects of microwave-assisted and ethanol maceration of marjoram (Origanum majorana) on MCF-7 breast cancer cell lines and normal breast tissue cell lines used as controls. Marjoram extracts displayed a cytotoxic effect on the MCF-7 cell lines and a mitogenic effect on the control cell lines at the MTS test. The metabolic profiles of MCF-7 and control cell lines were also assessed using the Biolog Phenotype Mammalian Metabolic (PM-M) platform and revealed statistically significant differences in the utilization of energy sources, metabolic activity in the presence of certain ionic species, and responses to metabolic effectors, such as stimulant/catabolic compounds and steroid hormones. Exposure to marjoram extracts exerted positive effects on the MCF-7 cells on the abnormal utilization of energy sources and the responses to metabolic effectors, while no major effects were detected on control cells. These effects were compared to the metabolic impact of the chemotherapeutic agent doxorubicin, which showed profound cytotoxic effects on both cancerous and normal breast cells. In conclusion, our in vitro evidence indicates that marjoram extracts are a promising alternative to chemotherapy in breast cancer since they can successfully eliminate cancerous cells by affecting their metabolic capacity to proliferate without inducing noticeable adverse effects on normal breast tissue.
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影响因子：
2.8
作者：
Mossa, A. T. H.;Nawwar, G. A. M.
通讯作者：
Nawwar, G. A. M.
影响因子：
--
作者：
Mouhid, Lamia;Gomez de Cedron, Marta;Ramirez de Molina, Ana
通讯作者：
Ramirez de Molina, Ana
影响因子：
4.7
作者：
Benhalilou, Nehia;Alsamri, Halima;Iratni, Rabah
通讯作者：
Iratni, Rabah
影响因子：
4.5
作者：
Al-Kalaldeh, Jelnar Z.;Abu-Dahab, Rana;Afifi, Fatma U.
通讯作者：
Afifi, Fatma U.
影响因子：
3.4
作者：
Abdellatif, Ahmed A. H.;Alsharidah, Mansour
通讯作者：
Alsharidah, Mansour