Surface-Functionalized Metal-Organic Frameworks for Binding Coronavirus Proteins.
Surface-Functionalized Metal-Organic Frameworks for Binding Coronavirus Proteins.
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DOI：
10.1021/acsami.2c21187
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发表时间：
2023-02-14
影响因子：
9.5
通讯作者：
Morris, Russell E.
中科院分区：
文献类型：
--
作者：
Desai, Aamod V.;Vornholt, Simon M.;Major, Louise L.;Ettlinger, Romy;Jansen, Christian;Rainer, Daniel N.;de Rome, Richard;So, Venus;Wheatley, Paul S.;Edward, Ailsa K.;Elliott, Caroline G.;Pramanik, Atin;Karmakar, Avishek;Armstrong, Robert;Janiak, Christoph;Smith, Terry K.;Morris, Russell E.
自从SARS-CoV-2爆发以来，人们探索了许多预防和屏蔽病毒颗粒的方法：过滤设备(PPE)在日常生活中得到了广泛的应用。在这项工作中，我们探索了另一种方法，通过选择性结合到金属有机骨架(MOF)表面来灭活冠状病毒颗粒，以进一步对抗呼吸道病毒的传播。在这方面，MOF是很有吸引力的材料，因为它们丰富的孔和表面化学成分可以很容易地根据需要进行修饰。三种MOF UIO-66(Zr)、UIO-66-NH2(Zr)和UIO-66-NO2(Zr)的表面已经被重新调整用途的抗病毒药物，即叶酸、制霉菌素和替诺福韦所功能化，以实现与SARS病毒外部刺突蛋白的特异性相互作用。蛋白质结合研究表明，这种表面修饰显著提高了三种MOF对糖化和非糖化蛋白质的结合亲和力。此外，表面功能化的MOF的孔可以吸附水，使它们适合于局部脱水微生物气溶胶。我们的发现突显了MOF在灭活呼吸道冠状病毒方面的巨大潜力，以便更好地装备起来抗击未来的大流行。
Since the outbreak of SARS-CoV-2, a multitude of strategies have been explored for the means of protection and shielding against virus particles: filtration equipment (PPE) has been widely used in daily life. In this work, we explore another approach in the form of deactivating coronavirus particles through selective binding onto the surface of metal–organic frameworks (MOFs) to further the fight against the transmission of respiratory viruses. MOFs are attractive materials in this regard, as their rich pore and surface chemistry can easily be modified on demand. The surfaces of three MOFs, UiO-66(Zr), UiO-66-NH2(Zr), and UiO-66-NO2(Zr), have been functionalized with repurposed antiviral agents, namely, folic acid, nystatin, and tenofovir, to enable specific interactions with the external spike protein of the SARS virus. Protein binding studies revealed that this surface modification significantly improved the binding affinity toward glycosylated and non-glycosylated proteins for all three MOFs. Additionally, the pores for the surface-functionalized MOFs can adsorb water, making them suitable for locally dehydrating microbial aerosols. Our findings highlight the immense potential of MOFs in deactivating respiratory coronaviruses to be better equipped to fight future pandemics.
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DOI：
10.1126/science.abg6296
发表时间：
2021-05-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cheng Y;Ma N;Witt C;Rapp S;Wild PS;Andreae MO;Pöschl U;Su H
通讯作者：
Su H
影响因子：
17.1
作者：
Konda, Abhiteja;Prakash, Abhinav;Guha, Supratik
通讯作者：
Guha, Supratik
影响因子：
24.2
作者：
Figueira, Flavio;Barbosa, Jessica S.;Almeida Paz, Filipe A.
通讯作者：
Almeida Paz, Filipe A.
影响因子：
9.5
作者：
Lazaro, Isabel Abanades;Haddad, Salame;Forgan, Ross S.
通讯作者：
Forgan, Ross S.
DOI：
10.1063/5.0037924
发表时间：
2021-02-01
期刊：
Physics of fluids (Woodbury, N.Y. : 1994)
影响因子：
--
作者：
Chatterjee S;Murallidharan JS;Agrawal A;Bhardwaj R
通讯作者：
Bhardwaj R