Topographical and temporal diversity of the human skin microbiome.

Topographical and temporal diversity of the human skin microbiome.
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DOI:
10.1126/science.1171700
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发表时间:
2009-05-29
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Segre JA
Segre JA
中科院分区:
其他
文献类型:
--
作者:
Grice EA;Kong HH;Conlan S;Deming CB;Davis J;Young AC;NISC Comparative Sequencing Program;Bouffard GG;Blakesley RW;Murray PR;Green ED;Turner ML;Segre JA

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人体皮肤是一个大的,异质的器官,保护身体免受病原体的侵害,同时维持影响人类健康和疾病的微生物。我们的16S核糖体RNA基因序列的分析,从20个不同的皮肤部位的健康人发现,生理上可比的网站窝藏相似的细菌群落。微生物群落的复杂性和稳定性取决于皮肤部位的具体特征。这种地形和时间调查为研究细菌群落在疾病状态中的作用以及维持健康皮肤所需的微生物相互依赖性提供了基线。
Human skin is a large, heterogeneous organ that protects the body from pathogens while sustaining microorganisms that influence human health and disease. Our analysis of 16S ribosomal RNA gene sequences obtained from 20 distinct skin sites of healthy humans revealed that physiologically comparable sites harbor similar bacterial communities. The complexity and stability of the microbial community are dependent on the specific characteristics of the skin site. This topographical and temporal survey provides a baseline for studies that examine the role of bacterial communities in disease states and the microbial interdependencies required to maintain healthy skin.
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