Neighborhood differences in exposure and sensitization to cockroach, mouse, dust mite, cat, and dog allergens in New York City.
Neighborhood differences in exposure and sensitization to cockroach, mouse, dust mite, cat, and dog allergens in New York City.
复制标题
DOI：
10.1016/j.jaci.2011.02.044
复制
发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Perzanowski MS
中科院分区：
文献类型：
--
作者：
Olmedo O;Goldstein IF;Acosta L;Divjan A;Rundle AG;Chew GL;Mellins RB;Hoepner L;Andrews H;Lopez-Pintado S;Quinn JW;Perera FP;Miller RL;Jacobson JS;Perzanowski MS
纽约市不同社区的哮喘患病率差异很大。接触老鼠和蟑螂过敏原被认为是原因之一。为了验证高哮喘患病率社区（HAPN）儿童家中蟑螂和小鼠过敏原浓度高于低哮喘患病率社区（LAPN）儿童的假设，并且这些暴露可能与致敏和哮喘有关。在纽约市邻里哮喘和过敏研究中，一项哮喘病例对照研究，通过相同的中等收入健康保险计划招募来自HAPN （n=120）和LAPN （n=119）的7-8岁儿童。根据报告的症状或药物使用情况，将儿童分为哮喘病例（n=128）和非哮喘对照组（n=111）。在床尘中测量过敏原。与LAPN家庭相比，HAPN家庭的Bla g2 （P=0.001）、Mus m1 （P=0.003）和Fel d1 （P=0.003）较高，Der f1 （P=0.001）较低。室内过敏原致敏与哮喘相关，但相关过敏原在LAPN和HAPN之间存在差异。HAPN儿童对蜚蠊致敏率高于LAPN儿童（23.7%比10.8%，P=0.011）。增加过敏原暴露与蟑螂（P<0.001）、尘螨（P=0.009）和猫（P=0.001）的致敏性（IgE）增加有关，但与小鼠（P=0.58）和狗（P=0.85）无关。这些发现进一步证明了蟑螂和老鼠在城市社区暴露和致敏的相关性，并表明蟑螂过敏原暴露可能导致纽约市某些社区的哮喘患病率高于其他社区。
Asthma prevalence varies widely among neighborhoods within New York City. Exposure to mouse and cockroach allergens has been suggested as a cause. To test the hypotheses that children living in high asthma prevalence neighborhoods (HAPN) would have higher concentrations of cockroach and mouse allergens in their homes than children in low asthma prevalence neighborhoods (LAPN), and that these exposures would be related to sensitization and asthma. In the NYC Neighborhood Asthma and Allergy Study, a case-control study of asthma, 7–8 year old children from HAPN (n=120) and LAPN (n=119) were recruited through the same middle-income health insurance plan. Children were classified as asthma cases (n=128) or non-asthma controls (n=111) based on reported symptoms or medication use. Allergens were measured in bed dust. HAPN homes had higher Bla g 2 (P=0.001), Mus m 1 (P=0.003) and Fel d 1 (P=0.003) and lower Der f 1 (P=0.001) than LAPN homes. Sensitization to indoor allergens was associated with asthma, but relevant allergens differed between LAPN and HAPN. Sensitization to cockroach was more common among HAPN than LAPN children (23.7% vs. 10.8%, P=0.011). Increasing allergen exposure was associated with increased probability of sensitization (IgE) to cockroach (P<0.001), dust mite (P=0.009) and cat (P=0.001), but not mouse (P=0.58) or dog (P=0.85). These findings further demonstrate the relevance of exposure and sensitization to cockroach and mouse in an urban community and suggest that cockroach allergen exposure could contribute to the higher asthma prevalence observed in some compared with other NYC neighborhoods.
登录
查看更多内容
影响因子：
5.8
作者：
Chew, GL;Correa, JC;Perzanowski, MS
通讯作者：
Perzanowski, MS
影响因子：
14.2
作者：
Chew, Ginger L.;Perzanowski, Matthew S.;Jacobson, Judith S.
通讯作者：
Jacobson, Judith S.
影响因子：
6.1
作者：
Matricardi, P. M.;Bockelbrink, A.;Lau, S.
通讯作者：
Lau, S.
影响因子：
14.2
作者：
Busse, William W.
通讯作者：
Busse, William W.
影响因子：
10.4
作者：
Cohn RD;Arbes SJ Jr;Jaramillo R;Reid LH;Zeldin DC
通讯作者：
Zeldin DC