Cardiovascular risks in relation to posttraumatic stress severity among young trauma-exposed women.
Cardiovascular risks in relation to posttraumatic stress severity among young trauma-exposed women.
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DOI：
10.1016/j.jad.2018.08.007
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发表时间：
2018-12-01
影响因子：
6.6
通讯作者：
Beckham JC
中科院分区：
文献类型：
--
作者：
Kibler JL;Ma M;Tursich M;Malcolm L;Llabre MM;Greenbarg R;Gold SN;Beckham JC
创伤后应激与心血管疾病（CVD）的风险增加有关。相对较少的研究，特别是在女性中，已经记录了PTSD可能在成年早期赋予CVD风险的机制。本研究的目的是检查是否有数量和相对水平的心血管疾病的危险因素与创伤后应激症状的严重程度之间的年轻，创伤暴露的妇女。参与者是年龄在19-49岁的绝经前妇女，她们有不同程度的创伤后应激障碍，没有慢性疾病史（n=54），并从精神卫生诊所和普通社区招募。创伤后应激的严重程度进行了评估与结构化的临床访谈（临床医生管理PTSD量表）。评估的心血管疾病风险因素包括血脂（总胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白）、静息血压（BP）、体重指数（BMI）、典型周内不运动和吸烟。创伤后应激的严重程度与较低的高密度脂蛋白水平和较高的甘油三酯水平，较高的收缩压和舒张压，较高的BMI，以及更多的总CVD危险因素有关。主要的限制是有限数量的参与者显示出一些CVD风险因素的临床水平（例如，BP）。尽管如此，大多数参与者表现出一种以上的CVD风险因素，这表明在这个相对年轻的样本中，许多女性在以后的生活中有可能面临更大的风险。目前的研究结果支持的论点，即在没有医疗疾病，创伤后应激症状的严重程度在年轻女性与几个心血管疾病的危险因素在生命早期。
Posttraumatic stress is associated with elevated risk for cardiovascular disease (CVD). Relatively little research, particularly among women, has documented mechanisms by which PTSD might confer CVD risk during early adulthood. The purpose of the present study was to examine whether the number and relative levels of CVD risk factors are associated with posttraumatic stress symptom severity among young, trauma-exposed women. Participants were premenopausal women ages 19–49 with varying levels of posttraumatic stress and no history of chronic medical illness (n=54), and were recruited from mental health clinics and the general community. Posttraumatic stress severity was assessed with a structured clinical interview (Clinician-Administered PTSD Scale). The CVD risk factors assessed were lipids (total cholesterol, triglycerides, high- and low-density lipoproteins), resting blood pressure (BP), body mass index (BMI), no exercise in typical week, and cigarette smoking. Posttraumatic stress severity was associated with lower high-density lipoprotein levels and higher triglycerides, greater systolic and diastolic BP, greater BMI, and a greater number of total CVD risk factors. The main limitation is the limited number of participants who displayed clinical levels on some of the CVD risk factors (e.g., BP). Nonetheless, most participants exhibited more than one CVD risk factor, indicating the potential for many of the women in this relatively young sample to progress toward greater risk later in life. The present results support the contention that, in the absence of medical illness, posttraumatic stress symptom severity among young women is associated with several CVD risk factors early in life.
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影响因子：
2.3
作者：
Kibler, Jeffrey L.;Joshi, Kavita;Ma, Mindy
通讯作者：
Ma, Mindy
影响因子：
10.6
作者：
Kagan, BL;Leskin, G;Foy, D
通讯作者：
Foy, D
影响因子：
2.2
作者：
Dedert, Eric A.;Harper, Leia A.;Calhoun, Patrick S.;Dennis, Michelle F.;Beckham, Jean C.
通讯作者：
Beckham, Jean C.
影响因子：
4.2
作者：
Kubzansky, Laura D.;Koenen, Karestan C.;Eaton, William W.
通讯作者：
Eaton, William W.
影响因子：
5.1
作者：
Jordan, Hannah T.;Miller-Archie, Sara A.;Stellman, Steven D.
通讯作者：
Stellman, Steven D.