Lymphocytic sialadenitis of Sjögren's syndrome associated with chronic hepatitis C virus liver disease.
Lymphocytic sialadenitis of Sjögren's syndrome associated with chronic hepatitis C virus liver disease.
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DOI：
10.1016/0140-6736(92)91645-o
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发表时间：
1992-02-08
期刊：
影响因子：
--
通讯作者：
Beaugrand M
中科院分区：
文献类型：
--
作者：
Haddad J;Deny P;Munz-Gotheil C;Ambrosini JC;Trinchet JC;Pateron D;Mal F;Callard P;Beaugrand M
病毒感染通常被认为是干燥综合征或慢性淋巴细胞性涎腺炎的可能原因，并且在患有这种疾病的患者的唾液腺中发现了EB病毒。在我们注意到几名感染丙型肝炎病毒（HCV）的患者出现干燥综合征后，我们建立了一项前瞻性研究，以调查慢性淋巴细胞性涎腺炎（有或无症状）与慢性HCV肝病的关系。将确诊为HCV肝炎或肝硬化的患者唇唾液腺的组织学表现与死亡对照组进行比较。与对照组（1/20，5%）相比，HCV感染患者（16/28，57%）的干燥综合征特征性组织学变化明显更常见。Sjögren综合征特征性的局灶性淋巴细胞性涎腺炎（尽管只有10例患者有口干症，没有人主诉干眼症）似乎在慢性HCV肝病患者中很常见;如果这种关联得到证实，识别潜在的机制可能会提高我们对这两种疾病的理解。
Viral infection has often been suggested as a possible cause of Sjögren's syndrome or chronic lymphocytic sialadenitis, and Epstein-Barr virus has been found in the salivary glands of patients with this condition. After we had noted Sjögren's syndrome in several patients infected with hepatitis C virus (HCV), a virus also excreted in saliva, we set up a prospective study to investigate the association of chronic lymphocytic sialadenitis, with or without symptoms, to chronic HCV liver disease. The histological appearances of labial salivary glands in patients with proven HCV hepatitis or cirrhosis were compared with those in dead controls. Histological changes characteristic of Sjögren's syndrome were significantly more common in HCV-infected patients (16 of 28, 57%) compared with controls (1 of 20, 5%). Focal lymphocytic sialadenitis characteristic of Sjögren's syndrome (though only 10 patients had xerostomia and none complained of xerophthalmia) appears to be common in patients with chronic HCV liver disease; if this association is confirmed, identification of the underlying mechanism may improve our understanding of both disorders.
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DOI：
10.1016/0030-4220(74)90417-4
发表时间：
1974-01-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
GREENSPAN, JS;DANIELS, TE;SYLVESTER, RA
通讯作者：
SYLVESTER, RA
影响因子：
13.5
作者：
KNODELL, RG;ISHAK, KG;WOLLMAN, J
通讯作者：
WOLLMAN, J
影响因子：
--
作者：
GOLDING, PL;BOWN, R;TAYLOR, E
通讯作者：
TAYLOR, E
影响因子：
168.9
作者：
MCFARLANE, IG;SMITH, HM;WILLIAMS, R
通讯作者：
WILLIAMS, R
影响因子：
5.9
作者：
MARIETTE, X;GOZLAN, J;MORINET, F
通讯作者：
MORINET, F