Origin and Evolution of the Gene Family of Proteinaceous Pheromones, the Exocrine Gland-Secreting Peptides, in Rodents.
Origin and Evolution of the Gene Family of Proteinaceous Pheromones, the Exocrine Gland-Secreting Peptides, in Rodents.
复制标题
DOI：
10.1093/molbev/msaa220
复制
发表时间：
2021-01-23
影响因子：
10.7
通讯作者：
Touhara K
中科院分区：
文献类型：
--
作者：
Niimura Y;Tsunoda M;Kato S;Murata K;Yanagawa T;Suzuki S;Touhara K
外分泌腺分泌肽（ESP）基因家族编码的蛋白质信息素是由犁鼻器识别的小鼠。例如，ESP1是分泌在泪液中的雄性信息素，调节社会性行为，ESP22是抑制成年性行为的青少年信息素。该家族由多个基因组成，仅在小鼠和大鼠基因组中被鉴定。小鼠ESP基因的编码区被分成两个外显子，每个外显子编码信号和成熟序列。在这里，我们报告的ESP基因家族的起源和进化。ESP基因仅在鼠科和仓鼠科中发现，表明ESP基因在鼠科和仓鼠科的共同祖先中最近起源。ESP基因在不同物种和小鼠品系之间在数量、长度和序列上表现出很大的多样性。在大鼠和金黄地鼠中，一些ESP在泪腺和唾液腺中表达。我们还发现ESP基因的成熟序列与α-珠蛋白基因显示出整体序列相似性。祖先ESP基因似乎是通过逆转录转座的α-珠蛋白基因与位于ESP基因簇附近的CRISP2基因的信号编码外显子重组而产生的。这项研究提供了一个有趣的例子，在快速发展的物种特异性蛋白质信息素基因的分子修补。
The exocrine-gland secreting peptide (ESP)gene family encodes proteinaceous pheromones that are recognized by the vomeronasal organ in mice. For example, ESP1 is a male pheromone secreted in tear fluid that regulates socio-sexual behavior, and ESP22 is a juvenile pheromone that suppresses adult sexual behavior. The family consists of multiple genes and has been identified only in mouse and rat genomes. The coding region of a mouse ESP gene is separated into two exons, each encoding signal and mature sequences. Here, we report the origin and evolution of the ESP gene family. ESP genes were found only in the Muridea and Cricetidae families of rodents, suggesting a recent origin of ESP genes in the common ancestor of murids and cricetids. ESP genes show a great diversity in number, length, and sequence among different species as well as mouse strains. Some ESPs in rats and golden hamsters are expressed in the lacrimal gland and the salivary gland. We also found that a mature sequence of an ESP gene showed overall sequence similarity to the α-globin gene. The ancestral ESP gene seems to be generated by recombination of a retrotransposed α-globin gene with the signal-encoding exon of the CRISP2 gene located adjacent to the ESP gene cluster. This study provides an intriguing example of molecular tinkering in rapidly evolving species-specific proteinaceous pheromone genes.
登录
查看更多内容
DOI：
10.1038/nrg2487
发表时间：
2009-01
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.7
作者：
Cabanettes F;Klopp C
通讯作者：
Klopp C
影响因子：
64.8
作者：
Haga, Sachiko;Hattori, Tatsuya;Touhara, Kazushige
通讯作者：
Touhara, Kazushige
哺乳动物信息素。
影响因子：
18.2
作者：
Liberles SD
通讯作者：
Liberles SD
影响因子：
10.7
作者：
Kumar, Sudhir;Stecher, Glen;Tamura, Koichiro
通讯作者：
Tamura, Koichiro