Presinusoidal vessels predominantly contract in response to norepinephrine, histamine, and KCl in rabbit liver.
Presinusoidal vessels predominantly contract in response to norepinephrine, histamine, and KCl in rabbit liver.
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窦前血管主要响应兔肝脏中的去甲肾上腺素、组胺和 KCl 而收缩。
DOI：
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发表时间：
1999
影响因子：
3.3
通讯作者：
S. Koyama
中科院分区：
文献类型：
--
作者：
T. Shibamoto;H. ;T. Miyahara;S. Tanaka;H. Haniu;S. Koyama
在兔肝脏中，肝血管的哪些节段主要由各种血管收缩剂收缩尚不清楚。我们测定了组胺、去甲肾上腺素和KCl对离体兔肝的肝血管阻力分布的影响，该离体兔肝经门静脉以恒定流速灌注5%白蛋白-Krebs溶液。采用双血管闭塞压法（Pdo）测定肝毛细血管压，并测定门静脉阻力（Rpv）和肝静脉阻力（Rhv）。团注组胺或去甲肾上腺素剂量依赖性地增加门静脉压，但不Pdo，导致Rpv剂量依赖性增加，Rhv无变化。KCl（50 mM），当注入顺行灌注的肝脏，收缩窦前血管选择性与肝脏重量损失。尽管KCl显著增加了逆行灌注肝脏中的Rhv，但Rpv增加基线的400%超过了Rhv增加基线的85%。在逆行灌注的肝脏中，KCl产生了最初的肝脏重量减轻，随后是深刻的重量增加。我们的结论是组胺和去甲肾上腺素选择性收缩窦前血管。KCl效应的结果表明，这种选择性的窦前收缩可能是由于功能活跃的血管平滑肌主要分布在窦前血管而不是肝静脉。
In rabbit livers, it is not well known which segments of the hepatic vasculature are predominantly contracted by various vasoconstrictors. We determined effects of histamine, norepinephrine, and KCl on hepatic vascular resistance distribution in isolated rabbit livers perfused via the portal vein with 5% albumin-Krebs solution at a constant flow rate. Hepatic capillary pressure was measured by double vascular occlusion pressure (Pdo) and was used to determine portal (Rpv) and hepatic venous (Rhv) resistances. A bolus injection of either histamine or norepinephrine dose-dependently increased portal venous pressure but not Pdo, resulting in a dose-dependent increase in Rpv and no changes in Rhv. KCl (50 mM), when injected in anterogradely perfused livers, contracted the presinusoidal vessels selectively with liver weight loss. Although KCl significantly increased Rhv in retrogradely perfused livers, the increase in Rpv by 400% of baseline predominated over the increase in Rhv by 85% of baseline. In the retrogradely perfused livers, KCl produced an initial liver weight loss followed by a profound weight gain. We conclude that histamine and norepinephrine selectively contract the presinusoidal vessels. The results on KCl effects suggest that this selective presinusoidal constriction might be possibly due to predominant distribution of functionally active vascular smooth muscle in the presinusoidal vessels rather than the hepatic vein in rabbit livers.
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