Pilot multimodal twin imaging study of generalized anxiety disorder.
Pilot multimodal twin imaging study of generalized anxiety disorder.
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DOI：
10.1002/da.20901
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发表时间：
2012-03
影响因子：
7.4
通讯作者：
Fatouros, Panos
中科院分区：
文献类型：
--
作者：
Hettema, John M.;Kettenmann, Birgit;Ahluwalia, Vishwadeep;McCarthy, Christopher;Kates, Wendy R.;Schmitt, James E.;Silberg, Judy L.;Neale, Michael C.;Kendler, Kenneth S.;Fatouros, Panos
关键词：
Generalized anxiety disorder (GAD) is a common, chronic condition that is relatively understudied compared to other psychiatric syndromes. Neuroimaging studies have begun to implicate particular neural structures and circuitry in its pathophysiology; however, no genetically-informative research has examined the potential sources of reported brain differences. We acquired spectroscopic, volumetric, and diffusion tensor magnetic resonance imaging data from a pilot study of 34 female subjects selected from monozygotic twin pairs based upon their affection status for GAD and examined brain regions previously implicated in fear and anxiety for their relationship with affection status and genetic risk. Lifetime GAD associated with increased creatine levels in the amygdala, smaller left hippocampal volume, and lower fractional anisotropy in the uncinate fasciculus which connects amygdala and frontal cortex. In addition, GAD genetic risk predicted increases in myo-inositol in the amygdala and, possibly, glutamate/glutamine/GABA alterations in the hippocampus. The association of lifetime GAD with smaller hippocampal volume was independent of major depression and might represent a common genetic risk marker for internalizing disorders. These preliminary data suggest that GAD and its genetic risk factors are likely correlated with volumetric and spectroscopic changes in fear-related limbic structures and their connections with the frontal cortex.
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影响因子：
17.7
作者：
Hettema, JM;Neale, MC;Kendler, KS
通讯作者：
Kendler, KS
DOI：
10.1523/jneurosci.2335-09.2009
发表时间：
2009-09-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kim MJ;Whalen PJ
通讯作者：
Whalen PJ
影响因子：
2.3
作者：
Kates, WR;Abrams, MT;Reiss, AL
通讯作者：
Reiss, AL
影响因子：
10.6
作者：
Hettema, John M.;An, Seon-Sook;Chen, Xiangning
通讯作者：
Chen, Xiangning
影响因子：
--
作者：
Kendler, KS;Prescott, CA
通讯作者：
Prescott, CA