Altered Odor-Induced Brain Activity as an Early Manifestation of Cognitive Decline in Patients With Type 2 Diabetes
Altered Odor-Induced Brain Activity as an Early Manifestation of Cognitive Decline in Patients With Type 2 Diabetes
复制标题
气味引起的大脑活动改变是 2 型糖尿病患者认知能力下降的早期表现
DOI：
10.2337/db17-1274
复制
发表时间：
2018-03
期刊：
影响因子：
7.7
通讯作者：
Zhu Dalong
中科院分区：
文献类型：
--
作者：
Zhang Zhou;Zhang Bing;Wang Xin;Zhang Xin;Yang Qing X.;Qing Zhao;Lu Jiaming;Bi Yan;Zhu Dalong
据报道，2型糖尿病与嗅觉功能障碍和认知能力下降有关。然而，嗅觉神经回路异常是否以及如何涉及糖尿病的认知功能障碍仍然没有发现。因此，本研究旨在研究嗅觉网络的改变以及气味诱导的大脑活动与2型糖尿病患者认知和代谢参数的相关性。认知正常的参与者，包括51名2型糖尿病患者和41名无糖尿病的对照受试者，接受了详细的认知评估，嗅觉行为测试和气味诱导的功能性MRI测量。选择两组之间显示出显著不同激活的嗅觉脑区域进行功能连接分析。与对照组相比，糖尿病患者表现出明显较低的嗅觉阈值评分，大脑激活减少，嗅觉网络的功能连接中断。在糖尿病患者中观察到功能连接中断与神经心理学测试分数降低和胰腺功能降低的正相关性。值得注意的是，胰腺功能和执行功能之间的关联是由嗅觉行为和嗅觉功能连接介导的。我们的研究结果表明，嗅觉网络的改变存在于临床可测量的认知功能减退之前的2型糖尿病，桥接中枢嗅觉系统和认知功能减退之间的差距。
Type 2 diabetes is reported to be associated with olfactory dysfunction and cognitive decline. However, whether and how olfactory neural circuit abnormalities involve cognitive impairment in diabetes remains uncovered. This study thus aimed to investigate olfactory network alterations and the associations of odor-induced brain activity with cognitive and metabolic parameters in type 2 diabetes. Participants with normal cognition, including 51 patients with type 2 diabetes and 41 control subjects without diabetes, underwent detailed cognitive assessment, olfactory behavior tests, and odor-induced functional MRI measurements. Olfactory brain regions showing significantly different activation between the two groups were selected for functional connectivity analysis. Compared with the control subjects, patients with diabetes demonstrated significantly lower olfactory threshold score, decreased brain activation, and disrupted functional connectivity in the olfactory network. Positive associations of the disrupted functional connectivity with decreased neuropsychology test scores and reduced pancreatic function were observed in patients with diabetes. Notably, the association between pancreatic function and executive function was mediated by olfactory behavior and olfactory functional connectivity. Our results suggested the alteration of olfactory network is present before clinically measurable cognitive decrements in type 2 diabetes, bridging the gap between the central olfactory system and cognitive decline in diabetes.
登录
查看更多内容
影响因子：
2.9
作者：
Wang J;Eslinger PJ;Doty RL;Zimmerman EK;Grunfeld R;Sun X;Meadowcroft MD;Connor JR;Price JL;Smith MB;Yang QX
通讯作者：
Yang QX
影响因子：
4.6
作者：
Zhang Y;Lu S;Liu C;Zhang H;Zhou X;Ni C;Qin W;Zhang Q
通讯作者：
Zhang Q
影响因子：
8.2
作者：
HAVRANKOVA, J;BROWNSTEIN, M;ROTH, J
通讯作者：
ROTH, J
DOI：
10.1016/s0140-6736(17)31363-6
发表时间：
2017-12-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Livingston, Gill;Sommerlad, Andrew;Mukadam, Naaheed
通讯作者：
Mukadam, Naaheed
影响因子：
2.9
作者：
DOTY, RL;SHAMAN, P;DANN, M
通讯作者：
DANN, M