Olfactory deficit detected by fMRI in early Alzheimer's disease.
Olfactory deficit detected by fMRI in early Alzheimer's disease.
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DOI：
10.1016/j.brainres.2010.08.018
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发表时间：
2010-10-21
期刊：
影响因子：
2.9
通讯作者：
Yang QX
中科院分区：
文献类型：
--
作者：
Wang J;Eslinger PJ;Doty RL;Zimmerman EK;Grunfeld R;Sun X;Meadowcroft MD;Connor JR;Price JL;Smith MB;Yang QX
根据心理物理测试的结果，阿尔茨海默病 (AD) 伴有嗅觉功能障碍。目前尚不清楚通过功能性磁共振成像 (fMRI) 测量的中枢嗅觉系统神经活动中与 AD 相关的改变是否能够在健康老年人中观察到。此外，尚不清楚这种变化是否与气味感知和痴呆指数相关。为了研究这些问题，12 名早期 AD 患者和 13 名非痴呆对照者在暴露于三种浓度的薰衣草油气味剂的同时接受了功能磁共振成像。所有参与者均接受了宾夕法尼亚大学气味识别测试 (UPSIT)、简易精神状态检查 (MMSE)、马蒂斯痴呆评定量表 2 (DRS-2) 和临床痴呆评定量表 (CDR)。 AD 受试者初级嗅觉皮层 (POC) 的血氧水平依赖性 (BOLD) 信号弱于 HC 受试者。在最低气味浓度下，POC、海马和岛叶内的 BOLD 信号与 UPSIT、MMSE、DRS-2 和 CDR 评分显着相关。在 AD 组中，POC 内的 BOLD 信号强度和激活量随气味浓度的变化而显着增加，但在对照组中则不然。这些发现表明嗅觉功能磁共振成像对 AD 相关的嗅觉和功能性认知下降很敏感。
Alzheimer’s disease (AD) is accompanied by smell dysfunction, as measured by psychophysical tests. Currently it is unknown whether AD-related alterations in central olfactory system neural activity, as measured by functional magnetic resonance imaging (fMRI), are detectable beyond those observed in healthy elderly. Moreover, it is not known whether such changes are correlated with indices of odor perception and dementia. To investigate these issues, twelve early stage AD patients and thirteen non-demented controls underwent fMRI while being exposed to each of three concentrations of lavender oil odorant. All participants were administered the University of Pennsylvania Smell Identification Test (UPSIT), the Mini-Mental State Examination (MMSE), the Mattis Dementia Rating Scale-2 (DRS-2), and the Clinical Dementia Rating Scale (CDR). The Blood oxygen level-dependent (BOLD) signal at primary olfactory cortex (POC) was weaker in AD than in HC subjects. At the lowest odorant concentration, the BOLD signals within POC, hippocampus, and insula were significantly correlated with UPSIT, MMSE, DRS-2, and CDR scores. The BOLD signal intensity and activation volume within the POC increased significantly as a function of odorant concentration in the AD group, but not in the control group. These findings demonstrate that olfactory fMRI is sensitive to the AD-related olfactory and functional cognitive decline.
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