Sympathetic nerve fibers in human cervical and thoracic vagus nerves.
Sympathetic nerve fibers in human cervical and thoracic vagus nerves.
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人类颈迷走神经和胸迷走神经中的交感神经纤维。
DOI：
10.1016/j.hrthm.2014.04.032
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发表时间：
2014-08
期刊：
影响因子：
5.5
通讯作者：
Fishbein, Michael C.
中科院分区：
文献类型：
--
作者：
Seki, Atsuko;Green, Hunter R.;Lee, Thomas D.;Hong, LongSheng;Tan, Jian;Vinters, Harry V.;Chen, Peng-Sheng;Fishbein, Michael C.
迷走神经刺激疗法（VNS）已用于慢性心力衰竭（CHF），并且被认为通过增加副交感神经活动来改善自主控制的不平衡。尽管已知VN和颈交感干之间存在神经通信，但是关于VN内交感成分的数量和/或分布的数据很少。研究人类VN内的交感神经成分，并将其与心脏和神经系统疾病的存在相关联。我们对31例尸检的人颈胸VN（共104例VN）进行了免疫组织化学染色，并回顾了患者的记录。我们将VN内交感神经纤维的数量与心血管和神经疾病状态相关联。104个VN均含有TH阳性（交感）神经纤维，平均TH阳性面积分别为：右颈VN 5.47%，左颈VN 3.97%，右胸VN 5.11%，左胸VN 4.20%。TH阳性神经纤维的分布因病例而异：中央，周围，或分散在整个神经束。在VNS被认为有效的疾病（抑郁症和CHF）与其他心血管疾病或神经退行性疾病之间，神经形态没有统计学显著差异。人类VN含有交感神经纤维。VN内的交感成分可能在VNS报告的生理效应中起作用。对迷走神经中交感神经纤维的识别有助于更好地理解迷走神经综合征的治疗机制。
Vagus nerve stimulation therapy (VNS) has been used for chronic heart failure (CHF), and is believed to improve imbalance of autonomic control by increasing parasympathetic activity. Although it is known that there is neural communication between the VN and the cervical sympathetic trunk, there are few data regarding the quantity and/or distribution of the sympathetic components within the VN. To examine the sympathetic component within human VN and correlate these with the presence of cardiac and neurologic diseases. We performed immunohistochemistry on 31 human cervical and thoracic VNs (total 104 VNs) from autopsies and we reviewed the patients’ records. We correlated the quantity of sympathetic nerve fibers within the VNs with cardiovascular and neurologic disease states. All 104 VNs contain TH positive (sympathetic) nerve fibers; the mean TH positive areas were 5.47% in right cervical, 3.97% in left cervical, 5.11% in right thoracic, and 4.20% in left thoracic VN. The distribution of TH positive nerve fibers varied from case to case: central, peripheral, or scattered throughout nerve bundles. No statistically significant differences in nerve morphology were seen between diseases in which VNS is considered effective (depression and CHF), and other cardiovascular diseases, or neurodegenerative disease. Human VNs contain sympathetic nerve fibers. The sympathetic component within the VN could play a role in physiologic effects reported with VNS. The recognition of sympathetic nerve fibers in the VNs may lead to better understanding of the therapeutic mechanisms of VNS.
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影响因子：
2
作者：
Kawagishi, Kyutaro;Fukushima, Nanae;Moriizumi, Tetsuji
通讯作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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影响因子：
5.5
作者：
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通讯作者：
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