In vivo chlorine and sodium MRI of rat brain at 21.1 T.
In vivo chlorine and sodium MRI of rat brain at 21.1 T.
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DOI：
10.1007/s10334-013-0387-2
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Brey WW
中科院分区：
文献类型：
--
作者：
Schepkin VD;Elumalai M;Kitchen JA;Qian C;Gor'kov PL;Brey WW
在21.1 T的磁场中对低γ核进行MR成像，为了解各种生物过程提供了新的机会。其中，氯和钠因其参与脑功能和癌症发展而引起关注。在21.1T磁场下，对正常大鼠（n = 3）和胶质瘤大鼠（n = 3）进行了35Cl和23Na的MRI扫描，并测量了其弛豫时间。使用中心向外反投影法评价两个核的浓度。用双指数函数拟合了氯在正常大鼠头部的T1弛豫曲线（T1a = 4.8ms（0.7），T1b = 24.4 ± 7ms（0.3）），并与钠的T1曲线（T1 = 41.4ms）进行了比较。体内氯和钠的自由诱导衰减（FID）是双指数的， ms和 MS，分别。评估了小采集矩阵和双指数FID对大鼠脑中氯（33.2 mM）和钠（44.4 mM）定量的影响。该研究模拟了双指数衰减对MRI结果的显著影响。相对于正常大脑，胶质瘤中氯浓度的增加（约1.5倍）与断言氯对肿瘤进展的重要性的假设相关。
MR imaging of low-gamma nuclei at the ultrahigh magnetic field of 21.1 T provides a new opportunity for understanding a variety of biological processes. Among these, chlorine and sodium are attracting attention for their involvement in brain function and cancer development. MRI of 35Cl and 23Na were performed and relaxation times were measured in vivo in normal rat (n = 3) and in rat with glioma (n = 3) at 21.1 T. The concentrations of both nuclei were evaluated using the center-out back-projection method. T1 relaxation curve of chlorine in normal rat head was fitted by bi-exponential function (T1a = 4.8 ms (0.7) T1b = 24.4 ± 7 ms (0.3) and compared with sodium (T1 = 41.4 ms). Free induction decays (FID) of chlorine and sodium in vivo were bi-exponential with similar rapidly decaying components of ms and ms, respectively. Effects of small acquisition matrix and bi-exponential FIDs were assessed for quantification of chlorine (33.2 mM) and sodium (44.4 mM) in rat brain. The study modeled a dramatic effect of the bi-exponential decay on MRI results. The revealed increased chlorine concentration in glioma (~1.5 times) relative to a normal brain correlates with the hypothesis asserting the importance of chlorine for tumor progression.
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