Investigation of potential injectable polymeric biomaterials for bone regeneration.
Investigation of potential injectable polymeric biomaterials for bone regeneration.
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DOI：
10.1002/jbm.a.34521
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发表时间：
2013-08
影响因子：
4.9
通讯作者：
Jayasuriya, Ambalangodage C.
中科院分区：
文献类型：
--
作者：
Dreifke, Michael B.;Ebraheim, Nabil A.;Jayasuriya, Ambalangodage C.
本文综述了目前正在研究的潜在的可注射聚合物生物材料支架在骨组织再生中的应用。综述了可注射生物材料支架的两种类型，包括可注射微球和可注射凝胶。可注射微球部分包括几种聚合物材料，包括聚(L-丙交酯-乙交酯)-聚乙交酯、聚富马酸丙二酯和壳聚糖。可注射凝胶部分包括海藻酸凝胶、透明质酸水凝胶、聚乙二醇-聚乙二醇水凝胶和聚乙二醇聚乳酸共聚物水凝胶。本文从聚合物材料的生物降解性、生物相容性、孔隙率、微球大小和交联性等方面综述了聚合物在体内外对细胞行为的影响。可注射聚合物生物材料为骨科应用提供了一个主要优势，因为它能够使用非侵入性或微侵入性的治疗方法。因此，将可注射聚合物生物材料支架与细胞相结合，在治疗骨科骨缺损方面具有重要的潜力，包括脊柱融合、颅面和牙周缺损。
This article reviews the potential injectable polymeric biomaterial scaffolds currently being investigated for application in bone tissue regeneration. Two types of injectable biomaterial scaffolds are focused in this review, including injectable microspheres and injectable gels. The injectable microspheres section covers several polymeric materials, including poly(l-lactide-co-glycolide)-PLGA, poly (propylene fumarate), and chitosan. The injectable gel section covers alginate gels, hyaluronan hydrogels, poly(ethylene-glycol)-PEG hydrogels, and PEG-PLGA copolymer hydrogels. This review focuses on the effect of cellular behaviorin vitro andin vivo in terms of material properties of polymers, such as biodegradation, biocompatibility, porosity, microsphere size, and cross-linking nature. Injectable polymeric biomaterials offer a major advantage for orthopedic applications by allowing the ability to use noninvasive or minimally invasive treatment methods. Therefore, combining injectable polymeric biomaterial scaffolds with cells have a significant potential to treat orthopedic bone defects, including spine fusion, and craniofacial and periodontal defects.
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影响因子：
4.9
作者：
Briggs, Tonye;Treiser, Matthew D.;Arinzeh, Treena Livingston
通讯作者：
Arinzeh, Treena Livingston
影响因子：
14
作者：
Gyawali, Dipendra;Nair, Parvathi;Yang, Jian
通讯作者：
Yang, Jian
DOI：
10.1159/000223687
发表时间：
2009-01-01
期刊：
CALCIUM AND BONE DISORDERS IN CHILDREN AND ADOLESCENTS
影响因子：
--
作者：
Grabowski, Peter
通讯作者：
Grabowski, Peter
影响因子：
14
作者：
Hedberg, EL;Shih, CK;Mikos, AG
通讯作者：
Mikos, AG
影响因子：
6.2
作者：
Betz, Martha W.;Yeatts, Andrew B.;Fisher, John P.
通讯作者：
Fisher, John P.