Baseline psychosocial predictors of survival in localised breast cancer.
Baseline psychosocial predictors of survival in localised breast cancer.
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DOI：
10.1038/sj.bjc.6603091
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发表时间：
2006-05-08
影响因子：
8.8
通讯作者：
Kellokumpu-Lehtinen, P
中科院分区：
文献类型：
--
作者：
Lehto, US;Ojanen, M;Dyba, T;Aromaa, A;Kellokumpu-Lehtinen, P
尽管有大量关于心理社会因素对乳腺癌进展的影响的研究，但对其中涉及的促成因素或过程尚不确定。我们调查了社会经济、心理和心理社会因素对乳腺癌患者生存率的相对影响。连续抽样调查72岁以下乳腺癌患者102例(参与率82%)，在确诊后3−4个月完成有效问卷，内容包括癌症应对、情绪表达(愤怒)、感知可获得的支持、非癌症生活压力和生活质量。生存时间是从确诊之日到复发之日，再到死亡之日或最后一次随访之日。进行累积COX回归分析。在控制了生物学预后因素、年龄和基线治疗后，较长的教育和与最小化相关的应对措施预测了较长的生存期，而较短的生存期则通过情绪防御(反情绪性)、行为逃避应对和高水平的感知支持来预测。失业和抑郁症状也预示着更短的无事故时间。癌症的存活率受到心理社会因素的复杂组合的影响，其中最小化预示着有利的预后，而愤怒不表达和逃避行为则预示着不利的预后。较高的社会经济地位与较长的生存时间相关。幸福感量表中的高分可能反映了情绪的不表达。
Despite the large number of studies on the impact of psychosocial factors on breast cancer progression, there is no certainty about the contributing factors or processes involved. We investigated the relative impacts of socioeconomic, psychological, and psychosocial factors on survival in breast cancer. A consecutive sample of 102 patients (participation 82%) under 72 years of age with locoregional breast cancer completed validated questionnaires on coping with cancer, emotional expression (anger), perceived available support, noncancer life stresses, and quality of life 3−4 months after diagnosis. Survival times were measured from the date of diagnosis to the date of relapse and further to the date of death or date of last follow-up. Cumulative Cox regression analyses were carried out. After controlling for biological prognostic factors, age, and baseline treatment, longer survival was predicted by a long education and a minimising-related coping, while shorter survival was predicted by emotional defensiveness (antiemotionality), behavioural-escape coping, and a high level of perceived support. A shorter event-free time was also predicted by unemployment and depressive symptoms. Cancer survival is affected by a complex combination of psychosocial factors, among which minimising predicts a favourable prognosis and anger nonexpression and escape behaviour an unfavourable prognosis. Higher socioeconomic status is associated with longer survival. High scores in well-being scales may reflect emotional nonexpression.
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影响因子：
8.8
作者：
de Haes JC;van Knippenberg FC;Neijt JP
通讯作者：
Neijt JP
影响因子：
3.3
作者：
COBB, S
通讯作者：
COBB, S
影响因子：
4.3
作者：
FernandezBallesteros, R;Zamarron, MD;Spielberger, CD
通讯作者：
Spielberger, CD
影响因子：
7.6
作者：
FOLKMAN, S;LAZARUS, RS;GRUEN, RJ
通讯作者：
GRUEN, RJ
影响因子：
22.8
作者：
FORSEN, A
通讯作者：
FORSEN, A