Long term changes to auditory sensitivity following blast trauma in mice.
Long term changes to auditory sensitivity following blast trauma in mice.
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DOI：
10.1016/j.heares.2021.108201
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发表时间：
2021-04
期刊：
影响因子：
2.8
通讯作者：
Dent ML
中科院分区：
文献类型：
--
作者：
Burke K;Manohar S;Dent ML
爆炸创伤是现代战争中常见的声/物理损伤。20%的现役军人接近爆炸，并经历轻度至严重的感觉障碍。这种损伤的发生率很高，但将听觉灵敏度变化与初始损伤相关联是困难的，因为损伤和评估通常相隔很长时间。在这里，听觉灵敏度测量之前和之后的创伤性爆炸在成年CBA/CaJ小鼠使用听觉脑干反应，失真产生耳声发射，和纯音的行为检测。这些测量包括所有小鼠在损伤前的基线听觉灵敏度，以及两个生理组在爆炸后3、30和90天的听觉灵敏度，以及行为组在90天内的每日听觉灵敏度。所有组的小鼠都经历了听觉灵敏度的最初恶化，尽管生理测量显示出恢复的证据，而行为测量没有。ABR波的振幅和潜伏期可能反映了阈值变化所显示的外周损害之外的其他变化，应进一步探讨。目前的工作解决了一个主要的差距，在目前的声创伤文献比较生理和行为的方法，以及测量恢复的时间过程。
Blast trauma is a common acoustic/physical insult occurring in modern warfare. Twenty percent of active duty military come into close proximity to explosions and experience mild to severe sensory deficits. The prevalence of such injuries is high but correlating auditory sensitivity changes with the initial insult is difficult because injury and evaluations are often separated by long time periods. Here, auditory sensitivity was measured before and after a traumatic blast in adult CBA/CaJ mice using auditory brainstem responses, distortion production otoacoustic emissions, and behavioral detection of pure tones. These measurements included baseline auditory sensitivity prior to injury in all mice, and again at 3, 30, and 90 days after the blast in the two physiological groups, and daily for up to 90 days in the behavioral group. Mice in all groups experienced an initial deterioration in auditory sensitivity, though physiological measurements showed evidence of recovery that behavioral measurements did not. Amplitudes and latencies of ABR waves may reflect additional changes beyond the peripheral damage shown by the threshold changes and should be explored further. The present work addresses a major gap in the current acoustic trauma literature both in terms of comparing physiological and behavioral methods, as well as measuring the time course of recovery.
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影响因子：
4.2
作者：
Kobrina A;Schrode KM;Screven LA;Javaid H;Weinberg MM;Brown G;Board R;Villavisanis DF;Dent ML;Lauer AM
通讯作者：
Lauer AM
影响因子：
2.8
作者：
Kobrina, Anastasiya;Dent, Micheal L.
通讯作者：
Dent, Micheal L.
DOI：
10.1523/jneurosci.2845-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kujawa SG;Liberman MC
通讯作者：
Liberman MC
DOI：
10.1007/s10162-010-0228-1
发表时间：
2010-12-01
影响因子：
2.4
作者：
Ohlemiller, Kevin K.;Dahl, Ashley R.;Gagnon, Patricia M.
通讯作者：
Gagnon, Patricia M.
影响因子：
4.6
作者：
Kraus, Nina;Thompson, Elaine C.;LaBella, Cynthia R.
通讯作者：
LaBella, Cynthia R.