Access to a running wheel decreases cocaine-primed and cue-induced reinstatement in male and female rats.
Access to a running wheel decreases cocaine-primed and cue-induced reinstatement in male and female rats.
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DOI：
10.1016/j.drugalcdep.2011.08.006
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发表时间：
2012-02-01
影响因子：
4.2
通讯作者：
Lang, Kimberly C.
中科院分区：
文献类型：
--
作者：
Smith, Mark A.;Pennock, Michael M.;Walker, Katherine L.;Lang, Kimberly C.
戒毒一段时间后复吸是可卡因依赖治疗中的一个长期问题。体力活动减少了实验室动物的可卡因自我管理，并与人类药物滥用人群的积极预后有关。本研究的目的是研究长期接触转轮对雄性和雌性大鼠可卡因寻求行为的药物启动和线索诱导恢复的影响。在断奶时获得Long-Evans大鼠，并在研究期间将其分配到久坐（无轮子）和运动（使用轮子）组。6周后，大鼠被植入静脉导管，并接受14天的自我注射可卡因训练。训练结束后，用生理盐水代替可卡因，让反应消失，然后在两组中检查可卡因引发的恢复。在该试验后，在两组中重新建立可卡因自我给药，持续5天。接下来，第二个禁欲期发生，可卡因和可卡因相关的线索都被扣留。戒断5天后，两组均检查了线索诱导的恢复。久坐不动和运动的大鼠表现出相似的可卡因自我管理水平，但运动大鼠的反应比久坐不动的大鼠在灭绝。在可卡因引发和线索诱导的恢复测试中，运动大鼠的反应低于久坐不动的大鼠，这种影响在雄性和雌性中都很明显。这些数据表明，长期接触转轮可减少药物引发和线索诱导的复吸，而且体力活动可能有效预防药物滥用人群的复吸。
Relapse to drug use after a period of abstinence is a persistent problem in the treatment of cocaine dependence. Physical activity decreases cocaine self-administration in laboratory animals and is associated with a positive prognosis in human substance-abusing populations. The purpose of this study was to examine the effects of long-term access to a running wheel on drug-primed and cue-induced reinstatement of cocaine-seeking behavior in male and female rats. Long-Evans rats were obtained at weaning and assigned to sedentary (no wheel) and exercising (access to wheel) groups for the duration of the study. After 6 weeks, rats were implanted with intravenous catheters and trained to self-administer cocaine for 14 days. After training, saline was substituted for cocaine and responding was allowed to extinguish, after which cocaine-primed reinstatement was examined in both groups. Following this test, cocaine self-administration was re-established in both groups for a 5-day period. Next, a second period of abstinence occurred in which both cocaine and the cocaine-associated cues were withheld. After 5 days of abstinence, cue-induced reinstatement was examined in both groups. Sedentary and exercising rats exhibited similar levels of cocaine self-administration, but exercising rats responded less than sedentary rats during extinction. In tests of cocaine-primed and cue-induced reinstatement, exercising rats responded less than sedentary rats, and this effect was apparent in both males and females. These data indicate that long-term access to a running wheel decreases drug-primed and cue-induced reinstatement, and that physical activity may be effective at preventing relapse in substance-abusing populations.
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影响因子：
2.9
作者：
KENT, S;HURD, M;SATINOFF, E
通讯作者：
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