Omega-3 fatty acid supplement use and oxidative stress levels in pregnancy.
Omega-3 fatty acid supplement use and oxidative stress levels in pregnancy.
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DOI：
10.1371/journal.pone.0240244
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Ferguson KK
中科院分区：
文献类型：
--
作者：
Sley EG;Rosen EM;van 't Erve TJ;Sathyanarayana S;Barrett ES;Nguyen RHN;Bush NR;Milne GL;Swan SH;Ferguson KK
氧化应激是活性氧和抗氧化剂的生物失衡。怀孕期间氧化应激增加与不良的出生结果有关。补充Omega-3脂肪酸（n-3 FA）可以降低氧化应激;然而，这种关系在怀孕期间很少被检查。本研究评估了妊娠期间使用n-3 FA补充剂与尿液氧化应激生物标志物浓度之间的相关性。数据来自婴儿发育与环境研究（TIDES），这是一项前瞻性队列研究，招募了2010-2012年间美国4个城市的孕妇。妊娠晚期n-3 FA摄入量是自我报告的。测量妊娠晚期尿8-异前列腺素F2α（8-iso-PGF 2 α）作为氧化应激生物标志物。此外，我们测定了8-iso-PGF 2 α和前列腺素F2α（PGF 2 α）的主要代谢产物，并利用8-iso-PGF 2 α与PGF 2 α的比值计算了反映氧化应激与炎症的8-iso-PGF 2 α变化。使用校正的线性模型确定与对照的混杂相关性。在725名妇女中，165名报告在妊娠晚期使用n-3 FA补充剂。在校正线性模型中，n-3 FA使用与8-iso-PGF 2 α水平降低10.2%（95%置信区间[CI]：-19.6，0.25）和代谢产物水平降低10.3%（95% CI：-17.1，2.91）相关。未观察到与PGF 2 α相关。8-iso-PGF 2 α水平较低似乎反映了氧化应激降低（补充剂用途：使用的百分比变化：-18.7，95% CI：-30.1，-5.32），而非炎症。总体而言，妊娠晚期n-3 FA摄入量与8-iso-PGF 2 α及其代谢产物浓度较低相关，表明妊娠期间母体氧化应激降低。
Oxidative stress is a biological imbalance in reactive oxygen species and antioxidants. Increased oxidative stress during pregnancy has been associated with adverse birth outcomes. Omega-3 fatty acid (n-3 FA) supplementation may decrease oxidative stress; however, this relationship is seldom examined during pregnancy. This study assessed the association between n-3 FA supplement use during pregnancy and urinary oxidative stress biomarker concentrations. Data came from The Infant Development and the Environment Study (TIDES), a prospective cohort study that recruited pregnant women in 4 US cities between 2010–2012. Third trimester n-3 FA intake was self-reported. Third trimester urinary 8-iso-prostaglandin F2α (8-iso-PGF2α) was measured as an oxidative stress biomarker. Additionally, we measured the major metabolite of 8-iso-PGF2α and Prostaglandin F2α (PGF2α) and utilized the 8-iso-PGF2α to PGF2α ratio to calculate the change in 8-iso-PGF2α reflecting oxidative stress versus inflammation. Adjusted linear models were used to determine associations with control for confounding. Of 725 women, 165 reported n-3 FA supplement use in the third trimester. In adjusted linear models, n-3 FA use was associated with 10.2% lower levels of 8-iso-PGF2α (95% Confidence Interval [CI]: -19.6, 0.25) and 10.3% lower levels of the metabolite (95% CI: -17.1, -2.91). No associations were observed with PGF2α. The lower levels of 8-iso-PGF2α appeared to reflect a decrease in oxidative stress (percent change with supplement use: -18.7, 95% CI: -30.1, -5.32) rather than inflammation. Overall, third trimester n-3 FA intake was associated with lower concentrations of 8-iso-PGF2α and its metabolite, suggesting a decrease in maternal oxidative stress during pregnancy.
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影响因子：
3.9
作者：
Brantsaeter, Anne Lise;Haugen, Margaretha;Meltzer, Helle Margrete
通讯作者：
Meltzer, Helle Margrete
影响因子：
2.1
作者：
Biri, Aydan;Bozkurt, Nuray;Durak, Ilker
通讯作者：
Durak, Ilker
影响因子：
3.8
作者：
Jones, Megan L.;Mark, Peter J.;Waddell, Brendan J.
通讯作者：
Waddell, Brendan J.
影响因子：
3.6
作者：
Franke, Corinna;Demmelmair, Hans;Koletzko, Berthold
通讯作者：
Koletzko, Berthold
影响因子：
3.3
作者：
Barden, AE;Mori, TA;Prescott, SL
通讯作者：
Prescott, SL