Brain processing of a configural vs elemental odor mixture in the newborn rabbit
Brain processing of a configural vs elemental odor mixture in the newborn rabbit
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新生兔大脑对结构气味与元素气味混合物的处理
DOI：
10.1007/s00429-015-1055-2
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发表时间：
2016
影响因子：
3.1
通讯作者：
G. Coureaud
中科院分区：
文献类型：
--
作者：
Nanette Schneider;F. Datiche;D. Wilson;V. Gigot;T. Thomas;G. Ferreira;G. Coureaud
生物体一生都被化学复杂的气味所包围。个体如何处理混合物或整体混合物中的气味是神经行为学和化学感官的关键问题。这个问题是解决这里通过使用新生兔，它可以迅速适应一个新的刺激，通过单一协会与乳腺信息素。在适应乙基麦芽酚（气味剂B）后，幼仔对B和A′B′混合物（68/32比例）有行为反应，但对异丁酸乙酯（气味剂A）或AB混合物（30/70比例）无反应。这表明分别对A′B′和AB的基本和抽象感知。然后，我们探讨了这些混合物的加工的神经基板的假设，加工根据感知而变化。在出生后第3天将幼仔假条件化或条件化至B，然后在第4天暴露于B、A′B′或AB。Fos的表达是不相似的组之间（主要是在嗅球和后梨状皮质），这可能反映刺激的复杂性或条件反射效应的刺激的差异处理。因此，A′B′与AB中组分的比例导致嗅觉系统的差异激活，这可能有助于这些混合物的元素和结构感知。此外，再加上最近的行为数据，这突出表明，即使在相对不成熟的动物中也会发生嗅觉感知，强调了新生兔对探索气味混合物从分子到大脑和行为的处理的价值。
Organisms are surrounded throughout life by chemically complex odors. How individuals process an odorant within a mixture or a mixture as a whole is a key question in neuroethology and chemical senses. This question is addressed here by using newborn rabbits, which can be rapidly conditioned to a new stimulus by single association with the mammary pheromone. After conditioning to ethyl maltol (odorant B), pups behaviorally respond to B and an A′B′ mixture (68/32 ratio) but not to ethyl isobutyrate (odorant A) or an AB mixture (30/70 ratio). This suggests elemental and configural perception of A′B′ and AB, respectively. We then explored the neural substrates underlying the processing of these mixtures with the hypothesis that processing varies according to perception. Pups were pseudoconditioned or conditioned to B on postnatal day 3 before exposure to B, A′B′ or AB on day 4. Fos expression was not similar between groups (mainly in the olfactory bulb and posterior piriform cortex) suggesting a differential processing of the stimuli that might reflect either stimulus complexity or conditioning effect. Thus, the ratio of components in A′B′ vs AB leads to differential activation of the olfactory system which may contribute to elemental and configural percepts of these mixtures. In addition, together with recent behavioral data, this highlights that configural perception occurs even in relatively immature animals, emphasizing the value of the newborn rabbit for exploration of odor mixture processing from molecules to brain and behavior.
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影响因子：
2
作者：
Fletcher, Max L.;Chen, Wei R.
通讯作者：
Chen, Wei R.
影响因子：
9.8
作者：
Doucette W;Restrepo D
通讯作者：
Restrepo D
影响因子：
3.5
作者：
Salcedo, E;Zhang, CB;Restrepo, D
通讯作者：
Restrepo, D
影响因子：
15.9
作者：
Restrepo, Diego;Doucette, Wilder;Whitesell, Jennifer D.;McTavish, Thomas S.;Salcedo, Ernesto
通讯作者：
Salcedo, Ernesto
影响因子：
3.5
作者：
Haberly, LB
通讯作者：
Haberly, LB