A hypomagnetic field aggravates bone loss induced by hindlimb unloading in rat femurs.
A hypomagnetic field aggravates bone loss induced by hindlimb unloading in rat femurs.
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DOI：
10.1371/journal.pone.0105604
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Shang P
中科院分区：
文献类型：
--
作者：
Jia B;Xie L;Zheng Q;Yang PF;Zhang WJ;Ding C;Qian AR;Shang P
亚磁场是一种极弱的磁场，它比地磁场弱得多。在深空探索任务中，例如涉及在月球上长期停留和行星际旅行的任务，宇航员将经历涉及亚磁场和微重力的异常空间环境。众所周知，太空中的微重力会导致骨质流失，从而导致骨矿物质密度降低。然而，目前尚不清楚低磁场是否会影响骨骼系统。在本研究中，我们的目的是调查复杂的影响，低磁场和微重力对骨丢失。为研究低磁场对模拟失重大鼠股骨特征的影响，建立了低磁场暴露的大鼠后肢去负荷模型。我们使用地磁场屏蔽室来产生<300 nT的亚磁场。结果表明，低磁场可加重后肢去负荷大鼠的骨密度丢失，并改变股骨的生物力学特性。其机制可能涉及生物节律和微量元素浓度的变化，由于低磁场，这将导致在大鼠体内产生氧化应激反应。过量的活性氧会刺激成骨细胞分泌核因子-κB配体受体激活剂，促进破骨细胞的成熟和激活，最终导致骨吸收。
A hypomagnetic field is an extremely weak magnetic field—it is considerably weaker than the geomagnetic field. In deep-space exploration missions, such as those involving extended stays on the moon and interplanetary travel, astronauts will experience abnormal space environments involving hypomagnetic fields and microgravity. It is known that microgravity in space causes bone loss, which results in decreased bone mineral density. However, it is unclear whether hypomagnetic fields affect the skeletal system. In the present study, we aimed to investigate the complex effects of a hypomagnetic field and microgravity on bone loss. To study the effects of hypomagnetic fields on the femoral characteristics of rats in simulated weightlessness, we established a rat model of hindlimb unloading that was exposed to a hypomagnetic field. We used a geomagnetic field-shielding chamber to generate a hypomagnetic field of <300 nT. The results show that hypomagnetic fields can exacerbate bone mineral density loss and alter femoral biomechanical characteristics in hindlimb-unloaded rats. The underlying mechanism might involve changes in biological rhythms and the concentrations of trace elements due to the hypomagnetic field, which would result in the generation of oxidative stress responses in the rat. Excessive levels of reactive oxygen species would stimulate osteoblasts to secrete receptor activator of nuclear factor-κB ligand and promote the maturation and activation of osteoclasts and thus eventually cause bone resorption.
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DOI：
10.1016/j.ecl.2012.04.019
发表时间：
2012-09-01
影响因子：
4.5
作者：
Emkey, Ronald D.;Emkey, Gregory R.
通讯作者：
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影响因子：
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DOI：
10.1016/j.asr.2004.01.021
发表时间：
2004-01-01
期刊：
SPACE LIFE SCIENCES: LIFE SUPPORT SYSTEMS AND BIOLOGICAL SYSTEMS UNDER INFLUENCE OF PHYSICAL FACTORS
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作者：
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通讯作者：
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DOI：
10.1016/s0946-672x(99)80019-4
发表时间：
1999-07-01
影响因子：
3.5
作者：
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DOI：
10.1006/bbrc.2001.5747
发表时间：
2001-10-19
影响因子：
3.1
作者：
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通讯作者：
Melhus, H