Prevalence of osteoporosis in China: a meta-analysis and systematic review.
Prevalence of osteoporosis in China: a meta-analysis and systematic review.
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DOI：
10.1186/s12889-016-3712-7
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发表时间：
2016-10-03
影响因子：
4.5
通讯作者：
Hu Y
中科院分区：
文献类型：
--
作者：
Chen P;Li Z;Hu Y
我们进行了系统回顾和荟萃分析，以获得对中国骨质疏松症患病率的可靠估计并描述其流行病学特征。我们通过检索 2003 年至 2015 年 10 月在 PubMed、Web of Science、中国国家知识基础设施、万方和维普数据库中发表的文献确定了相关研究。中国和世界卫生组织的骨质疏松症诊断标准均被认为是可接受的。使用随机效应模型获得患病率估计。使用荟萃回归分析来探索异质性的来源，并通过目视检查漏斗图来评估发表偏倚。总体而言，本研究纳入了 69 篇文章。过去 12 年中骨质疏松症患病率明显上升（2008 年之前患病率为 14.94%，2012-2015 年期间患病率为 27.96%）。女性骨质疏松症患病率高于男性（25.41% vs. 15.33%），并且随着年龄的增长而增加。农村骨质疏松患病率高于城市（20.87% vs 23.92%），南方高于北方（23.17% vs 20.13%）。目前，50 岁及以上人群骨质疏松症的汇总患病率是 2006 年确定的汇总患病率的两倍多（34.65% 对比 15.7%）。不同诊断标准的应用可能会对患病率估计产生影响（19.7% vs. 29.3%）。荟萃回归表明研究背景也影响点患病率的估计（P = 0.022）。过去 12 年来，中国骨质疏松症患病率有所上升，影响了超过三分之一的 50 岁及以上人群。骨质疏松症的患病率随着年龄的增长而增加，并且女性高于男性。随着骨质疏松症患病率的上升，防控措施显得尤为重要，应实施三步预防方案。本文的在线版本 (doi:10.1186/s12889-016-3712-7) 包含补充材料，可供授权用户使用。
We conducted a systematic review and meta-analysis to obtain a reliable estimation of the prevalence of osteoporosis in China and to characterize its epidemiology. We identified relevant studies via a search of literature published from 2003 to October 2015 in the PubMed, Web of Science, China National Knowledge Infrastructure, Wanfang and Weipu databases. Both Chinese and WHO criteria were considered acceptable for the diagnosis of osteoporosis. Prevalence estimates were obtained using random effects models. Meta-regression analysis was used to explore the sources of heterogeneity, and publication bias was evaluated by visually inspecting funnel plots. Overall, 69 articles were included in this study. An obvious increase in the prevalence of osteoporosis was identified over the past 12 years (prevalence of 14.94 % before 2008 and 27.96 % during the period spanning 2012–2015). The prevalence of osteoporosis was higher in females than in males (25.41 % vs. 15.33 %) and increased with age. Osteoporosis prevalence was higher in rural than in urban areas (20.87 % vs. 23.92 %) and higher in southern than in northern areas (23.17 % vs. 20.13 %). At present, the pooled prevalence of osteoporosis in people aged 50 years and older was more than twice the pooled prevalence identified in 2006 (34.65 % vs. 15.7 %). The application of different diagnostic criteria could have an impact on prevalence estimation (19.7 % vs. 29.3 %). Meta-regression suggested that study setting also influenced the estimation of point prevalence (P = 0.022). The prevalence of osteoporosis in China has increased over the past 12 years, affecting more than one-third of people aged 50 years and older. The prevalence of osteoporosis increased with age and was higher in females than in males. Prevention and control measures have become all the more important given the increase in osteoporosis prevalence, and three-step prevention programmes should be implemented. The online version of this article (doi:10.1186/s12889-016-3712-7) contains supplementary material, which is available to authorized users.
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DOI：
10.1002/jbmr.2269
发表时间：
2014-11
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
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作者：
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