Bladder cancer and reproductive factors among women in Spain.
Bladder cancer and reproductive factors among women in Spain.
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DOI：
10.1007/s10552-009-9384-1
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发表时间：
2009-12
影响因子：
2.3
通讯作者：
Cantor, Kenneth P.
中科院分区：
文献类型：
--
作者：
Huang, An-Tsun;Kogevinas, Manolis;Silverman, Debra T.;Malats, Nuria;Rothman, Nathaniel;Tardon, Adonina;Serra, Consol;Garcia-Closas, Reina;Carrato, Alfredo;Cantor, Kenneth P.
可能与生殖特征有关的激素因素可能在女性膀胱癌风险中发挥作用。为了研究这一点，我们调查了生殖因素对女性膀胱癌风险的影响。在1998-2001年期间，从西班牙五个地区的18家医院收集了152例女性病例和166例匹配对照的个人访谈中有关生殖和其他风险因素的信息。Logistic回归分析用于评估膀胱癌与生殖因素之间的关系，包括经产状况、首次活产年龄、末次活产年龄、初潮年龄、绝经年龄、绝经状态和月经持续时间。在调整年龄、吸烟和高危职业后，经产妇女相对于未经产妇女的风险降低（比值比= 0.43，95%置信区间= 0.21-0.87）。与年龄或持续时间相关的生殖因素（例如，首次活产年龄、末次活产年龄、初潮年龄、绝经年龄、绝经状态和月经持续时间）。女性患膀胱癌的风险低于男性，与生育有关的激素因素可能起作用。
Hormonal factors, possibly related to reproductive characteristics, may play a role in the risk of bladder cancer among women. To study this, we investigated the effects of reproductive factors on female bladder cancer risk. Information on reproductive and other risk factors was gathered in personal interviews from 152 female cases and 166 matched controls from 18 hospitals in five regions of Spain during 1998–2001. Logistic regression was used to estimate the association between bladder cancer and reproductive factors, including ever-parous status, age at first live birth, age at last live birth, age at menarche, age at menopause, menopausal status, and duration of menstruation. After adjustment for age, smoking, and high-risk occupation, ever-parous women were at decreased risk relative to nulliparous women (odds ratio = 0.43, 95% confidence interval = 0.21–0.87). There was no consistent pattern in risk with the age- or duration-related reproductive factors (e.g., age at first live birth, age at last live birth, age at menarche, age at menopause, menopausal status, and duration of menstruation) that we evaluated. Women have a lower risk of bladder cancer than men, and hormonal factors related to childbearing may play a role.
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影响因子：
6.2
作者：
Shen, Steven S.;Smith, Carolyn L.;Lerner, Seth P.
通讯作者：
Lerner, Seth P.
影响因子：
6.6
作者：
Salmi, S;Santti, R;Mäkelä, S
通讯作者：
Mäkelä, S
影响因子：
2.1
作者：
Boorjian, S;Ugras, S;Scherr, DS
通讯作者：
Scherr, DS
影响因子：
4.1
作者：
Wilson, CM;McPhaul, MJ
通讯作者：
McPhaul, MJ
影响因子：
4.9
作者：
Samanic, C. M.;Kogevinas, M.;Dosemeci, M.
通讯作者：
Dosemeci, M.