Enhanced neuroactivation during verbal memory processing in postmenopausal women receiving short-term hormone therapy.
Enhanced neuroactivation during verbal memory processing in postmenopausal women receiving short-term hormone therapy.
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DOI：
10.1016/j.fertnstert.2008.04.040
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发表时间：
2009-07
影响因子：
6.7
通讯作者：
Smith YR
中科院分区：
文献类型：
--
作者：
Persad CC;Zubieta JK;Love T;Wang H;Tkaczyk A;Smith YR
采用随机、双盲、安慰剂对照的交叉设计，我们发现短期激素替代治疗增加了绝经后女性在言语记忆任务中顶叶和前额叶区域的大脑激活。目的：研究激素治疗对绝经后妇女言语记忆过程中脑激活模式的影响。进行了一项随机、双盲、安慰剂对照的交叉研究。三级护理大学医疗中心。10名健康绝经后妇女(年龄50~60岁)来自当地社区。女性被随机分组，按照她们接受联合激素治疗、5微克雌二醇和1毫克去甲基强的酮醋酸酯和安慰剂的顺序。志愿者接受激素治疗或安慰剂治疗4周，然后进行一个月的冲洗期，然后接受另一种治疗4周。在每4周治疗结束时，利用言语记忆任务进行功能磁共振检查。荷尔蒙治疗和安慰剂之间的脑激活模式被比较。在记忆编码过程中，激素治疗增加了左额中/上皮质(BA 6，9)、内侧额叶皮质和背侧前扣带回(BA 2 4，32)、后扣带回(BA 6)和左侧顶叶下部(BA 4 0)的激活。经多重比较校正后，所有区域的p≤均为0.0 5。在一项言语记忆任务中，激素治疗增加了绝经后女性额叶和顶叶区域的神经激活。
Using a randomized, double-blind placebo-controlled cross-over design, we showed that short-term hormone replacement therapy increases brain activation in parietal and prefrontal areas during verbal memory tasks in postmenopausal women. To study the effects of hormone therapy on brain activation patterns during verbal memory in postmenopausal women. A randomized, double-blind placebo-controlled cross-over study was performed. A tertiary care university medical center. Ten healthy postmenopausal women (age range 50-60 years) were recruited from the local community. Women were randomized to the order they received combined hormone therapy, 5 ug ethinyl estradiol and 1 mg norethindrone acetate, and placebo. Volunteers received hormone therapy or placebo for 4 weeks, followed by a one month washout period, and then received the other treatment for 4 weeks. An fMRI was performed at the end of each 4 week treatment utilizing a verbal memory task. Brain activation patterns were compared between hormone therapy and placebo. Hormone therapy was associated with increased activation in left middle/superior frontal cortex (BA 6,9), medial frontal cortex and dorsal anterior cingulate (BA 24,32), posterior cingulate (BA 6), and left inferior parietal (BA 40) during memory encoding. All regions were significant at p ≤ 0.05 with correction for multiple comparisons. Hormone therapy increased neural activation in frontal and parietal areas in postmenopausal women during a verbal memory task.
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影响因子：
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