Is Mindfulness Associated With Lower Pain Reactivity and Connectivity of the Default Mode Network? A Replication and Extension Study in Healthy and Episodic Migraine Participants.
Is Mindfulness Associated With Lower Pain Reactivity and Connectivity of the Default Mode Network? A Replication and Extension Study in Healthy and Episodic Migraine Participants.
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DOI：
10.1016/j.jpain.2022.07.011
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发表时间：
2022-12
期刊：
影响因子：
4
通讯作者：
Seminowicz, David A.
中科院分区：
文献类型：
--
作者：
Hunt, Carly A.;Letzen, Janelle E.;Krimmel, Samuel R.;Burrowes, Shana A. B.;Haythornthwaite, Jennifer A.;Finan, Patrick H.;Vetter, Maria;Seminowicz, David A.
基于正念的练习的正式训练可以减少实验和临床疼痛，这可能是由情绪疼痛反应的减少驱动的，并受到默认模式网络的改变的支持，涉及走神和自我参照处理。最近发表在这本杂志上的结果表明，正念，在这里定义为在没有训练的情况下保持非反应性精神状态的日常趋势，与较低的疼痛反应性，更高的热痛阈值和休息状态默认模式网络功能连接健康成年人以类似的方式训练正念。这些发现在多大程度上延伸到慢性疼痛样本和复制在健康样本是未知的。使用来自健康成人（n = 36）和发作性偏头痛患者（n = 98）的数据并复制先前发表的方法，我们观察到正念和热痛阈值，疼痛强度或不愉快，或健康对照组的疼痛灾难化之间没有显着关联，或者正念和头痛频率，严重程度，患者的冲击疼痛灾难化之间没有显着关联。通过基于种子的功能连接分析，在两个样本中，默认模式网络连接和正念之间没有关联。在事后全脑探索性分析中，元分析导出的默认模式网络节点（即，后扣带皮层）显示出与正念作用下的疼痛处理无关的区域的连通性，因此正念水平较高的健康成年人在后扣带皮层和小脑之间显示出更大的功能连通性。总的来说，这些研究结果表明，正念和默认模式网络功能连接之间的关系可能是微妙的或不稳定的，并鼓励进一步研究正念与疼痛的关系。这项研究发现，在健康成年人和偏头痛患者中，气质正念与疼痛、疼痛反应和默认模式连接之间几乎没有显著关联。正念和默认模式网络连接之间的关系可能是微妙的或非鲁棒的。
Formal training in mindfulness-based practices promotes reduced experimental and clinical pain, which may be driven by reduced emotional pain reactivity and undergirded by alterations in the default mode network, implicated in mind-wandering and self-referential processing. Recent results published in this journal suggest that mindfulness, defined here as the day-to-day tendency to maintain a non-reactive mental state in the absence of training, associates with lower pain reactivity, greater heat-pain thresholds, and resting-state default mode network functional connectivity in healthy adults in a similar manner to trained mindfulness. The extent to which these findings extend to chronic pain samples and replicate in healthy samples is unknown. Using data from healthy adults (n = 36) and episodic migraine patients (n = 98) and replicating previously published methods, we observed no significant association between mindfulness and heat-pain threshold, pain intensity or unpleasantness, or pain catastrophizing in healthy controls, or between mindfulness and headache frequency, severity, impactor pain catastrophizing in patients. There was no association between default mode network connectivity and mindfulness in either sample when probed via seed-based functional connectivity analyses. In post-hoc whole brain exploratory analyses, a meta-analytically derived default mode network node (i.e., posterior cingulate cortex) showed connectivity with regions unassociated with pain processing as a function of mindfulness, such that healthy adults higher in mindfulness showed greater functional connectivity between the posterior cingulate cortex-and cerebellum. Collectively, these findings suggest that the relationship between mindfulness and default mode network functional connectivity may be nuanced or non-robust, and encourage further investigation of how mindfulness relates to pain. This study found few significant associations between dispositional mindfulness and pain, pain reactivity and default mode connectivity in healthy adults and migraine patients. The relationship between mindfulness and default mode network connectivity may be nuanced or non-robust.
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