Association of environmental cadmium exposure with pediatric dental caries.
Association of environmental cadmium exposure with pediatric dental caries.
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DOI：
10.1289/ehp.10947
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发表时间：
2008-06
影响因子：
10.4
通讯作者：
Wright RO
中科院分区：
文献类型：
--
作者：
Arora M;Weuve J;Schwartz J;Wright RO
虽然动物实验表明镉暴露会导致严重的龋齿，但关于这个问题的流行病学数据有限。本研究旨在探讨环境镉暴露与6-12岁儿童龋齿的关系。我们分析了第三次全国健康与营养检查调查的横断面数据，包括尿镉浓度和蛀牙或填充牙齿表面的计数。我们使用逻辑和零膨胀负二项（ZINB）回归估计尿镉浓度和龋齿经验之间的关联，调整这些分析的潜在混杂因素，包括环境烟草烟雾（ETS）。尿镉浓度范围为0.01 - 3.38 ng/mL。大约56%的儿童在乳牙中经历过龋齿，近30%的儿童在恒牙列中受到龋齿的影响。肌酐校正的镉浓度（0.21 μg/g肌酐）的四分位距（IQR）增加对应于乳牙患龋几率增加16%[患病率比值比（OR）= 1.16; 95%置信区间（CI），0.96-1.40]。这种关联在低ETS暴露的儿童中具有统计学显著性（患病率OR = 1.30; 95%CI，1.01-1.67）。ZINB回归的结果表明，在乳牙有任何龋齿史的儿童中，镉的IQR增加与龋齿或填充表面数量增加17%相关。我们没有观察到镉和恒牙龋经验之间的关联。环境镉暴露可能与儿童乳牙龋齿风险增加有关。
Although animal experiments have shown that cadmium exposure results in severe dental caries, limited epidemiologic data are available on this issue. We aimed to examine the relationship between environmental cadmium exposure and dental caries in children 6–12 years of age. We analyzed cross-sectional data, including urine cadmium concentrations and counts of decayed or filled tooth surfaces, from the Third National Health and Nutrition Examination Survey. We used logistic and zero-inflated negative binomial (ZINB) regression to estimate the association between urine cadmium concentrations and caries experience, adjusting these analyses for potential confounders including environmental tobacco smoke (ETS). Urine cadmium concentrations ranged from 0.01 to 3.38 ng/mL. Approximately 56% of children had experienced caries in their deciduous teeth, and almost 30% had been affected by caries in their permanent dentition. An interquartile range (IQR) increase in creatinine-corrected cadmium concentrations (0.21 μg/g creatinine) corresponded to a 16% increase in the odds of having experienced caries in deciduous teeth [prevalence odds ratio (OR) = 1.16; 95% confidence interval (CI), 0.96–1.40]. This association was statistically significant in children with low ETS exposure (prevalence OR = 1.30; 95% CI, 1.01–1.67). The results from the ZINB regression indicated that, among children with any caries history in their deciduous teeth, an IQR increase in cadmium was associated with 17% increase in the number of decayed or filled surfaces. We observed no association between cadmium and caries experience in permanent teeth. Environmental cadmium exposure may be associated with increased risk of dental caries in deciduous teeth of children.
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DOI：
10.1111/j.1600-0528.2004.00155.x
发表时间：
2004-06-01
影响因子：
2.3
作者：
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通讯作者：
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影响因子：
3
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CURZON, MEJ;CROCKER, DC
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影响因子：
120.7
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通讯作者：
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影响因子：
10.4
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Bellinger DC
DOI：
10.1016/s1532-0456(03)00120-0
发表时间：
2003-07-01
影响因子：
3.9
作者：
Abdollahi, M;Bahreini-Moghadam, A;Zafari, K
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