Neuromodulation of Neural Oscillations in Health and Disease.
Neuromodulation of Neural Oscillations in Health and Disease.
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作者：
在过去的几十年里，脑电图（EEG）记录和大脑刺激的进步使人们对特定的大脑结构如何交流以及组织复杂的认知功能有了前所未有的了解。具体来说，神经递质（包括去甲肾上腺素、乙酰胆碱和多巴胺）都被证明对整个大脑的神经振荡有影响，将它们与认知功能（如记忆、注意力和执行功能）的变化联系起来。虽然这些相互作用仍然没有得到广泛的探索，但它们通过交叉频率耦合（CFC）在神经系统疾病中的出现，揭示了它们在协调健康大脑功能中发挥的重要作用。这篇简短的综述旨在强调每个神经调节系统在改变广泛的神经网络中所起的重要作用，强调它们与健康和疾病的关系，以帮助了解更多的翻译脑刺激技术。使用EEG和局部场电位（LFP）作为大规模神经活动的指标，研究已经能够将不同频带中的神经振荡与认知功能，目标导向行为和各种神经系统疾病的标记相关联。虽然这让我们得以一窥神经元如何在整个大脑中进行交流，但这些同步网络活动的因果关系仍然知之甚少。此外，主要神经调节系统（例如，去甲肾上腺素能、胆碱能和多巴胺能）对脑振荡的影响引起了广泛的关注。最近的研究表明，交叉频率耦合（CFC）在很大程度上负责介导跨皮层下和皮层大脑结构的网络范围内的通信，暗示了神经递质在形成协调行动中的重要性。通过揭示每个神经调节系统在调节全脑神经振荡中的作用，我们希望更清楚地了解神经振荡在各种认知功能和神经系统疾病中的关键作用，以及如何优化神经调节技术作为控制神经网络动力学的一种手段。这篇综述的目的是展示神经调节系统在大规模神经网络动力学中发挥的重要作用，为未来的研究提供信息，以密切关注它们参与神经振荡和相关行为的特定功能。
Over the past few decades, advances in electroencephalography (EEG) recordings and brain stimulation has permitted an unprecedented view of how specific brain structures communicate as well as organize complex cognitive functions. Specifically, neurotransmitters (including norepinephrine, acetylcholine, and dopamine) have all been shown to have an impact on neural oscillations throughout the brain, linking them to changes in cognitive functions such as memory, attention, and executive function. While these interactions are still widely unexplored, their appearance in neurological disorders through cross-frequency coupling (CFC) brings light to the vital role they play in orchestrating healthy brain function. This brief review serves to highlight the important role each neuromodulatory system plays in changing widespread neural networks, emphasizing their involvement in health and disease to help inform more translational brain stimulation technologies. Using EEG and local field potentials (LFPs) as an index of large-scale neural activities, research has been able to associate neural oscillations in different frequency bands with markers of cognitive functions, goal-directed behavior, and various neurological disorders. While this gives us a glimpse into how neurons communicate throughout the brain, the causality of these synchronized network activities remains poorly understood. Moreover, the effect of the major neuromodulatory systems (e.g., noradrenergic, cholinergic, and dopaminergic) on brain oscillations has drawn much attention. More recent studies have suggested that cross-frequency coupling (CFC) is heavily responsible for mediating network-wide communication across subcortical and cortical brain structures, implicating the importance of neurotransmitters in shaping coordinated actions. By bringing to light the role each neuromodulatory system plays in regulating brain-wide neural oscillations, we hope to paint a clearer picture of the pivotal role neural oscillations play in a variety of cognitive functions and neurological disorders, and how neuromodulation techniques can be optimized as a means of controlling neural network dynamics. The aim of this review is to showcase the important role that neuromodulatory systems play in large-scale neural network dynamics, informing future studies to pay close attention to their involvement in specific features of neural oscillations and associated behaviors.
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影响因子：
3.5
作者：
Andino-Pavlovsky V;Souza AC;Scheffer-Teixeira R;Tort ABL;Etchenique R;Ribeiro S
通讯作者：
Ribeiro S
影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
2.9
作者：
Ceni, Andrea;Olmi, Simona;Angulo-Garcia, David
通讯作者：
Angulo-Garcia, David
影响因子：
5.3
作者：
Busch, Niko A.;Dubois, Julien;VanRullen, Rufin
通讯作者：
VanRullen, Rufin