The use of dried blood spots for characterizing children's exposure to organic environmental chemicals.
The use of dried blood spots for characterizing children's exposure to organic environmental chemicals.
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DOI：
10.1016/j.envres.2021.110796
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发表时间：
2021-04
影响因子：
8.3
通讯作者：
Faustman EM
中科院分区：
文献类型：
--
作者：
Barr DB;Kannan K;Cui Y;Merrill L;Petrick LM;Meeker JD;Fennell TR;Faustman EM
生物监测是评估有机环境化学品暴露的常用工具，尿样和血样是最常用的基质。然而，对于儿童的学习，血液样本往往很难获得。干血斑点(DBS)是一种潜在的儿童采血基质，可用于生物监测。DBS通常是在出生时收集的，用于筛查几种先天性疾病和疾病；许多需要收集DBS的州将这些斑点存档多年。如果环境卫生研究人员可以访问存档的DBS，则可能会对它们进行分析，以追溯评估这些儿童的暴露情况。此外，可以在实地前瞻性地收集从新生儿到学龄儿童的DBS，父母几乎不关心，对儿童的风险也很小。在这里，我们回顾了对存档和预期收集的DBS中有机环境毒物的测量进行评估的研究，以及为确保这些测量与传统的生物监测测量相媲美而执行的验证程序。在迄今为止的研究中，验证的数量差异很大，没有研究系统地评估从现场收集、运输和储存污染和稳定性到实验室分析可行性的所有参数。这些验证研究对于确保测量的可靠性和与更传统的矩阵的可比性是必要的。因此，在DBS被采纳为生物监测的常规矩阵之前，我们为验证研究和其他考虑因素提供了一些建议。
Biomonitoring is a commonly used tool for exposure assessment of organic environmental chemicals with urine and blood samples being the most commonly used matrices. However, for children’s studies, blood samples are often difficult to obtain. Dried blood spots (DBS) represent a potential matrix for blood collection in children that may be used for biomonitoring. DBS are typically collected at birth to screen for several congenital disorders and diseases; many of the states that are required to collect DBS archive these spots for years. If the archived DBS can be accessed by environmental health researchers, they potentially could be analyzed to retrospectively assess exposure in these children. Furthermore, DBS can be collected prospectively in the field from children ranging in age from newborn to school-aged with little concern from parents and minimal risk to the child. Here, we review studies that have evaluated the measurement of organic environmental toxicants in both archived and prospectively collected DBS, and where available, the validation procedures that have been performed to ensure these measurements are comparable to traditional biomonitoring measurements. Among studies thus far, the amount of validation has varied considerably with no studies systematically evaluating all parameters from field collection, shipping and storage contamination and stability to laboratory analysis feasibility. These validation studies are requisite to ensure reliability of the measurement and comparability to more traditional matrices. Thus, we offer some recommendations for validation studies and other considerations before DBS should be adopted as a routine matrix for biomonitoring.
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