White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine.
White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine.
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DOI：
10.1016/j.drugalcdep.2017.01.011
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发表时间：
2017-05-01
影响因子：
4.2
通讯作者：
Potenza MN
中科院分区：
文献类型：
--
作者：
Morie KP;Yip SW;Zhai ZW;Xu J;Hamilton KR;Sinha R;Mayes LC;Potenza MN
产前可卡因暴露（PCE）与冒险行为有关，包括在青春期开始使用药物的增加。青少年PCE这些行为的神经生物学基础还不清楚。本研究的目的是使用交叉纤维模型比较有和没有PCE的青少年之间的弥散加权成像数据，该模型可以更全面地估计多个区域内的白质微结构（例如，初级和次级）纤维取向。从出生后的纵向队列中招募了39名PCE个体和17名高龄产前非药物暴露（NDE）青年。白色物质进行了检查，使用张量衍生和交叉纤维模型。进行全脑研究，分析7个白质区域，包括压部、胼胝体、双侧扣带回和左右上级纵束（SLF）。全脑分析显示没有组间差异。然而，来自交叉纤维模型的各向异性估计的ROI分析显示次级纤维的显著组间差异，与产前未暴露于右扣带和左SLF的青少年相比，PCE青少年的各向异性降低，并且在小脑的各向异性增加。我们的研究结果表明，在PCE青少年的白质差异是微妙的，主要集中在二级纤维的方向，可能是由于改变白质的发展。
Prenatal cocaine exposure (PCE) is associated with risk-taking behaviors, including increased initiation of substance use in adolescence. The neurobiological underpinnings of these behaviors in adolescents with PCE are not well understood. The goal of this study was to compare diffusion-weighted imaging data between adolescents with and without PCE using crossing-fiber models, which may provide more comprehensive estimates of white-matter microstructure within regions of multiple (e.g., primary and secondary) fiber orientations. Thirty-nine PCE individuals and 17 comparably aged prenatally non-drug-exposed (NDE) youths were recruited from a longitudinal cohort followed since birth. White matter was examined using tensor-derived and crossing-fiber models. Whole-brain investigations were performed, as were analyses on seven white-matter regions, which included the splenium, body and genu of the corpus callosum, bilateral cingulum, and the right and left superior longitudinal fasciculus (SLF). Whole-brain analyses revealed no group differences. However, ROI analyses for anisotropy estimates derived from the crossing-fiber model revealed significant group differences for secondary fibers, with reduced anisotropy among PCE adolescents compared to prenatally non-exposed youth in the right cingulum and the left SLF, and increased anisotropy in the genu. Our findings suggest that white-matter differences in PCE adolescents are subtle and localized primarily within secondary fiber orientations, perhaps arising from altered white-matter development.
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影响因子：
2.9
作者：
Galvan A
通讯作者：
Galvan A
影响因子：
11.3
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Lebel C;Warner T;Colby J;Soderberg L;Roussotte F;Behnke M;Davis Eyler F;Sowell ER
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通讯作者：
Sokol, Robert J.