The focal alteration and causal connectivity in children with new-onset benign epilepsy with centrotemporal spikes.
The focal alteration and causal connectivity in children with new-onset benign epilepsy with centrotemporal spikes.
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DOI：
10.1038/s41598-018-23336-z
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发表时间：
2018-04-09
影响因子：
4.6
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Chen S;Fang J;An D;Xiao F;Chen D;Chen T;Zhou D;Liu L
本研究的目的是在新发的良性儿童癫痫伴中央-颞叶棘波(BECTS)患儿中寻找癫痫灶并检查其与其他脑区的因果关系。对66例BECTS患儿和37例正常儿童进行静息状态功能磁共振成像(FMRI)检查。比较两组的低频波动(Alff)信号的幅度，找出潜在的致痫区(EZ)，然后用格兰杰因果分析(GCA)来探讨EZ对整个大脑的因果效应。BECTS患儿右侧Broca区Alff显著升高，双侧梭形回Alff显著降低。患者还表现出从Broca区的EZ到右侧前额叶的驱动作用增强，对额叶和语言网络后部的影响减弱。左侧韦尼克面积的因果效应与言语智商(VIQ)得分呈负相关。我们对新发BECTS患者的研究揭示了BECTS早期语言网络的一种可能的代偿机制，GCA和VIQ的负相关提示癫痫样活动对语言的干扰。这些发现为BECTS的发病机制和语言功能障碍提供了线索.
The aim of the current study was to find the epileptic focus and examine its causal relationship to other brain regions in children with new-onset benign childhood epilepsy with centrotemporal spikes (BECTS). Resting-state functional magnetic resonance imaging (fMRI) was performed in 66 children with BECTS and 37 matched control children. We compared the amplitude of low frequency fluctuation (ALFF) signals between the two groups to find the potential epileptogenic zone (EZ), then used Granger causality analysis (GCA) to explore the causal effects of EZ on the whole brain. Children with BECTS had significantly increased ALFF in the right Broca’s area, and decreased ALFF in bilateral fusiform gyrus. The patients also showed increased driving effect from the EZ in Broca’s area to the right prefrontal lobe, and decreased effects to the frontal lobe and posterior parts of the language network. The causal effect on left Wernicke’s area negatively correlated with verbal IQ (VIQ) score. Our research on new-onset BECTS patients illustrates a possible compensatory mechanism in the language network at early stages of BECTS, and the negative correlation of GCA and VIQ suggest the disturbance of epileptiform activity on language. These findings shed light on the mechanisms of and language dysfunction in BECTS.
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影响因子：
2.6
作者：
Ebus, S. C. M.;Overvliet, G. M.;Aldenkamp, A. P.
通讯作者：
Aldenkamp, A. P.
影响因子：
3.7
作者：
Ji GJ;Zhang Z;Zhang H;Wang J;Liu DQ;Zang YF;Liao W;Lu G
通讯作者：
Lu G
影响因子：
4.2
作者：
Besseling, Rene M. H.;Jansen, Jacobus F. A.;Backes, Walter H.
通讯作者：
Backes, Walter H.
影响因子：
5.6
作者：
Englot DJ;Konrad PE;Morgan VL
通讯作者：
Morgan VL
DOI：
10.1073/pnas.95.15.8939
发表时间：
1998-07-21
影响因子：
11.1
作者：
Horwitz, B;Rumsey, JM;Donohue, BC
通讯作者：
Donohue, BC