Neurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural China.
Neurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural China.
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DOI：
10.1038/s41598-021-86761-7
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发表时间：
2021-04-01
影响因子：
4.6
通讯作者：
Korrick SA
中科院分区：
文献类型：
--
作者：
Rothenberg SE;Chen Q;Shen J;Nong Y;Nong H;Trinh EP;Biasini FJ;Liu J;Zeng X;Zou Y;Ouyang F;Korrick SA
我们研究了儿童神经发育与其肠道微生物群组成之间的横断面关联。研究儿童（36 个月大）生活在中国农村 (n = 46)。使用婴儿发育贝利量表（第二版）评估神经发育，得出智力发育指数（MDI）和精神运动发育指数（PDI）。使用 16S rRNA 基因分析评估儿童肠道微生物群。使用α多样性模式来表征微生物多样性。此外，还确定了 25 个最丰富的类群的 3 个共丰度因子。构建多变量线性回归模型来检查贝利评分（MDI 和 PDI）与儿童肠道微生物群之间的关系。在调整后的模型中，MDI 和 PDI 评分与 alpha 多样性指数无关。然而，在调整后的模型中，MDI 和 PDI 评分与第一个共丰度因子呈正相关，该因子捕获了粪杆菌属、Sutterella 属和梭菌属 XIVa 簇的正载荷。对于第一个共丰度因子的四分位数范围的增加，MDI 分数增加了 3.9 分 [95% 置信区间 (CI)：0, 7.7]，而 PDI 分数增加了 8.6 分（95% CI 3.1, 14）。我们的结果强调了肠道微生物组成特征与 36 个月大儿童贝利量表表现的重要相关性。
We investigated cross-sectional associations between children’s neurodevelopment and their gut microbiota composition. Study children (36 months of age) lived in rural China (n = 46). Neurodevelopment was assessed using the Bayley Scales of Infant Development, 2nd Edition, yielding the Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI). Children's gut microbiota was assessed using 16S rRNA gene profiling. Microbial diversity was characterized using alpha diversity patterns. Additionally, 3 coabundance factors were determined for the 25 most abundant taxa. Multivariable linear regression models were constructed to examine the relationships between Bayley scores (MDI and PDI) and children's gut microbiota. In adjusted models, MDI and PDI scores were not associated with alpha diversity indices. However, in adjusted models, MDI and PDI scores were positively associated with the first coabundance factor, which captured positive loadings for the genera Faecalibacterium, Sutterella, and Clostridium cluster XIVa. For an interquartile range increase in the first coabundance factor, MDI scores increased by 3.9 points [95% confidence interval (CI): 0, 7.7], while PDI scores increased by 8.6 points (95% CI 3.1, 14). Our results highlight the potential for gut microbial compositional characteristics to be important correlates of children's Bayley Scales performance at 36 months of age.
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影响因子：
10.6
作者：
Carlson AL;Xia K;Azcarate-Peril MA;Goldman BD;Ahn M;Styner MA;Thompson AL;Geng X;Gilmore JH;Knickmeyer RC
通讯作者：
Knickmeyer RC
粘膜患病率和与上皮的相互作用表明Sutterella spp的相称。
影响因子：
5.2
作者：
Hiippala K;Kainulainen V;Kalliomäki M;Arkkila P;Satokari R
通讯作者：
Satokari R
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
2.4
作者：
Cheng J;Kalliomäki M;Heilig HG;Palva A;Lähteenoja H;de Vos WM;Salojärvi J;Satokari R
通讯作者：
Satokari R
影响因子：
15.1
作者：
Jiang, Haiyin;Ling, Zongxin;Ruan, Bing
通讯作者：
Ruan, Bing