Sex-dependent effects of nicotine on the developing brain.
Sex-dependent effects of nicotine on the developing brain.
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DOI：
10.1002/jnr.23878
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发表时间：
2017-01-02
影响因子：
4.2
通讯作者：
Leslie, Frances M.
中科院分区：
文献类型：
--
作者：
Cross, Sarah J.;Linker, Kay E.;Leslie, Frances M.
烟草制品的使用是一个重大的公共卫生问题，特别是在妇女中。流行病学数据一直表明，妇女戒烟成功率较低，患烟草相关疾病的风险较高。尼古丁的有害影响不仅限于成年期，因为尼古丁乙酰胆碱受体调节神经发育的关键方面。然而，妇女对烟草依赖特别敏感的确切机制尚未得到很好的阐明。在这篇综述中，我们表明，性腺激素介导的性分化的大脑可能是一个重要的决定因素的性别差异的尼古丁的影响。我们强调性类固醇激素和配体门控离子通道之间的直接相互作用对大脑成熟至关重要，并讨论了大脑的扩展和深刻的性别分化。我们强调，尼古丁暴露在围产期和青少年时期干扰正常的性分化，可以诱导持久的，性别依赖性的神经元结构，认知和执行功能，学习和记忆，奖励处理的改变。我们强调尼古丁作用的重要年龄和性别差异，并强调在模拟烟草依赖的临床前研究中包括这些因素的重要性。尼古丁作用的性别差异可能是由于围产期和青春期性腺激素介导的大脑性别分化。例如，在这些发育期暴露于尼古丁可以通过抑制芳香酶或诱导皮质酮释放而在神经元结构和功能中产生持久的性别依赖性变化。
The use of tobacco products represents a major public health concern, especially among women. Epidemiological data have consistently demonstrated that women have less success quitting tobacco use and a higher risk for developing tobacco-related diseases. The deleterious effects of nicotine are not restricted to adulthood, as nicotinic acetylcholine receptors regulate critical aspects of neural development. However, the exact mechanisms underlying the particular sensitivity of women to develop tobacco dependence have not been well elucidated. In this review, we show that gonadal hormone-mediated sexual differentiation of the brain may be an important determinant of sex differences in the effects of nicotine. We highlight direct interactions between sex steroid hormones and ligand-gated ion channels critical for brain maturation, and discuss the extended and profound sexual differentiation of the brain. We emphasize that nicotine exposure during the perinatal and adolescent periods interferes with normal sexual differentiation and can induce long-lasting, sex-dependent alterations in neuronal structure, cognitive and executive function, learning and memory, and reward processing. We stress important age and sex differences in nicotine’s effects and emphasize the importance of including these factors in preclinical research that models tobacco dependence. Sex differences in the effects of nicotine may be due to gonadal hormone-mediated sexual differentiation of the brain during the perinatal and adolescent periods. Exposure to nicotine during these developmental periods can produce long-lasting, sex-dependent changes in neuronal structure and function by inhibiting aromatase or inducing corticosterone release, for example.
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影响因子：
3.6
作者：
Cao, Junran;Belluzzi, James D.;Loughlin, Sandra E.;Dao, Jasmin M.;Chen, YiLing;Leslie, Frances M.
通讯作者：
Leslie, Frances M.
影响因子：
2.7
作者：
BECKER, JB;BEER, ME
通讯作者：
BEER, ME
影响因子：
1.7
作者：
Andersen, SL;Rutstein, M;Teicher, MH
通讯作者：
Teicher, MH
影响因子：
15.9
作者：
BARBIERI, RL;GOCHBERG, J;RYAN, KJ
通讯作者：
RYAN, KJ
影响因子：
2.5
作者：
Cao J;Dwyer JB;Gautier NM;Leslie FM;Li MD
通讯作者：
Li MD