Dissecting the biophysics and biology of intrinsically disordered proteins.
Dissecting the biophysics and biology of intrinsically disordered proteins.
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剖析本质上无序蛋白质的生物物理学和生物学。
DOI:
10.1016/j.tibs.2023.10.002
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发表时间:
2024
影响因子:
13.8
通讯作者:
Mendell,JoshuaT
中科院分区:
文献类型:
--
作者:
Banerjee,PriyaR;Holehouse,AlexS;Kriwacki,Richard;Robustelli,Paul;Jiang,Hao;Sobolevsky,AlexanderI;Hurley,JenniferM;Mendell,JoshuaT
Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current challenges in the field and propose cutting-edge approaches to address them in physiology and disease processes, with a focus on cancer.
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