Epstein-Barr virus-associated gastric carcinoma in Japanese Brazilians and non-Japanese Brazilians in São Paulo.
Epstein-Barr virus-associated gastric carcinoma in Japanese Brazilians and non-Japanese Brazilians in São Paulo.
复制标题
DOI：
10.1111/j.1349-7006.2001.tb01180.x
复制
发表时间：
2001-09
期刊：
影响因子：
--
通讯作者：
Tokunaga M
中科院分区：
文献类型：
--
作者：
Koriyama C;Akiba S;Iriya K;Yamaguti T;Hamada GS;Itoh T;Eizuru Y;Aikou T;Watanabe S;Tsugane S;Tokunaga M
在149例日本-巴西和151例非日本-巴西胃癌病例中，使用原位杂交（ISH）检测EB病毒编码的小RNA（EBER），检查EB-巴尔病毒相关胃癌（EB V-GC）的比例，并将结果与我们参考的日本数据进行比较。我们发现，4.7%的日本巴西人的病例是EBER阳性。这一频率略低于日本人，其中2038例胃癌病例中有6.2%为EBER阳性。另一方面，非日本-巴西系列显示EBV-GC的比例（11.2%）显著高于参考组（P=0.01）。虽然EBV-GC在非日裔巴西人的男性中占主导地位（M/ F=3.6，P=0.047），与日本人的情况相同（M/F=2.7），但日裔巴西人未显示出这种男性优势。日本巴西人和日本人之间的性别比差异具有统计学显著性（P=0.005）。总之，在日本巴西人和日本人中进行的本研究没有证据表明迁移引起的EBV-GC频率发生任何变化，除了在日本人和非日本巴西人中观察到的男性优势的缺乏。
The proportion of Epstein‐Barr virus‐associated gastric carcinoma (EB V‐GC) was examined in 149 Japanese‐Brazilian and 151 non‐Japanese‐Brazilian gastric‐carcinoma cases using in situ hybridization (ISH) assay to detect EBV‐encoded small RNA (EBER), and the results were compared with our referent Japanese data. We found that 4.7% of cases in Japanese Brazilians were EBER‐positive. This frequency was slightly lower than that of the referent Japanese, among whom 6.2% of 2038 gastric‐carcinoma cases were EBER‐positive. On the other hand, the non‐Japanese‐Brazilian series showed a significantly higher proportion of EBV‐GC (11.2%) than the referent group did (P=0.01). Although EBV‐GC was predominant in males among non‐Japanese Brazilians (M/ F=3.6, P=0.047), as was the case in Japanese (M/F=2.7), Japanese Brazilians did not show such a male predominance. The sex‐ratio difference between the Japanese Brazilians and Japanese was statistically significant (P=0.005). In conclusion, the present study in Japanese Brazilians and Japanese yielded no evidence suggesting any change in the frequency of EBV‐GC caused by migration, except the absence of male predominance, which was observed both in Japanese and non‐Japanese Brazilians.
登录
查看更多内容
影响因子：
2.3
作者：
TSUGANE, S;DESOUZA, JMP;WATANABE, S
通讯作者：
WATANABE, S
影响因子：
8.8
作者：
Sugiura, M;Imai, S;Tokunaga, M;Koizumi, S;Uchizawa, M;Okamoto, K;Osato, T
通讯作者：
Osato, T
DOI：
10.1097/00019606-199212000-00005
发表时间：
1992-12-01
期刊：
Diagnostic molecular pathology : the American journal of surgical pathology, part B
影响因子：
--
作者：
Chang, K L;Chen, Y Y;Weiss, L M
通讯作者：
Weiss, L M
影响因子：
6.4
作者：
OTT, G;KIRCHNER, T;MULLERHERMELINK, HK
通讯作者：
MULLERHERMELINK, HK
影响因子：
2.3
作者：
Kamineni, A;Williams, MA;Weiss, NS
通讯作者：
Weiss, NS