Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT.
Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT.
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DOI：
10.1371/journal.pone.0240110
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Huang AS
中科院分区：
文献类型：
--
作者：
Xie X;Corradetti G;Song A;Pardeshi A;Sultan W;Lee JY;Yu F;Zhang L;Chen S;Chopra V;Sadda SR;Xu B;Huang AS
采用一种新型扫源前段光学相干断层扫描（AS-OCT）设备，评估年龄和屈光状态对包括睫状体在内的前段解剖结构的影响。这项前瞻性观察性研究包括63名健康志愿者（平均年龄：44.2岁）。使用新的扫描源AS-OCT （ANTERION, Heidelberg Engineering GmbH, Heidelberg, Germany）获得前段图像，并对所有参与者的右眼进行跟踪和图像平均。评估了生物计量测量的可重复性以及观察者之间和观察者内部的可靠性。测试了图像跟踪和平均对睫状肌测量的影响。建立了单变量和多变量统计模型来评估年龄与前节屈光状态的关系。对于扫描源AS-OCT测量的所有测试-重测重复性以及观察者之间和观察者内部的重复性，高类内相关性（ICC）被注意到（0.88-1.00）。鼻部最大纤毛肌厚度（CMTMAX）和巩膜骨刺至纤毛肌最厚点的距离（SSMAX）均大于颞侧（p<0.001和p = 0.006）。鼻腔和颞部CMTMAX （p = 0.004和p<0.001）和晶状体厚度（p<0.01）随年龄增加而增加。鼻腔和颞部SSMAX随年龄增大和远视加重而降低（p = 0.01和p<0.001）。图像平均改善了睫状肌测量（p = 0.008至0.02）。晶状体拱顶随着年龄的增长和远视的增加而增加（p<0.01）。OCT测量角度随年龄增大和远视增加而降低（p<0.001 ~ 0.03）。随着年龄的增长，水深降低，远视增加（p<0.01）。瞳孔直径随年龄增大而减小（p<0.01）。使用ANTERION AS-OCT进行生物特征测量的重复性和再现性非常好。图像平均提高了纤毛肌测量的准确性。该设备产生的生物特征参数的测量，描述浅层和深层结构，包括睫状体和全晶状体厚度从一个单一的图像。
To assess the effects of age and refractive status on anterior segment anatomical structures, including the ciliary body, using a new swept-source anterior segment optical coherence tomography (AS-OCT) device. This prospective observational study included 63 healthy volunteers (mean age: 44.2 years). Images of the anterior segment were obtained using a new swept-source AS-OCT (ANTERION, Heidelberg Engineering GmbH, Heidelberg, Germany) with tracking and image averaging from the right eye of all participants. Repeatability as well as inter- and intra-observer reliability of biometric measurements were evaluated. The impact of image tracking and averaging on ciliary muscle measurements was tested. Univariate and multivariable statistical models were developed to evaluate the relationship of age and refractive status on anterior segment biometric measurements. For all test-retest repeatability and inter- and intra-observer reproducibility of swept-source AS-OCT measurements, high intraclass correlation (ICC) was noted (0.88–1.00). The nasal maximum ciliary muscle thickness (CMTMAX) and distance between scleral spur to the thickest point of the ciliary muscle (SSMAX) were larger than those on the temporal side (p<0.001 and p = 0.006, respectively). Nasal and temporal CMTMAX (p = 0.004 and p<0.001, respectively) and lens thickness (p<0.01) increased with age. Nasal and temporal SSMAX decreased with older age and increasing hyperopia (p = 0.01 and p<0.001, respectively). Image averaging resulted in improved ciliary muscle measurements (p = 0.008 to 0.02). Lens vault increased with older age and increased hyperopia (p<0.01). OCT measurements of the angle decreased with older age and increased hyperopia (p<0.001 to 0.03). Aqueous depth decreased with older age and increased hyperopia (p<0.01). Pupil diameter decreased with older age (p<0.01). Repeatability and reproducibility of biometric measurements using the ANTERION AS-OCT were excellent. Image averaging improved the accuracy of ciliary muscle measurements. The device produced measurements of biometric parameters that described superficial and deep structures including the ciliary body and full lens thickness from a single image.
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