Ethnic admixture affects diabetes risk in native Hawaiians: the Multiethnic Cohort.
Ethnic admixture affects diabetes risk in native Hawaiians: the Multiethnic Cohort.
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DOI：
10.1038/ejcn.2016.32
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发表时间：
2016-09
影响因子：
4.7
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中科院分区：
文献类型：
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夏威夷原住民（NH）的肥胖和糖尿病发病率很高，他们通常有混合血统。亚洲血统的人患2型糖尿病的风险很高，尽管他们的体重相对较低。我们在多种族队列（MEC）中评估了种族混合对NH糖尿病风险的影响。根据自我报告，11521名符合条件的男性和女性被分为NH/白人，NH/其他，NH单独，NH/亚洲，以及最常见的三种血统混合，NH/中国/白人。以NH/white组为参照组，计算Cox比例风险比（hr）和95%置信区间（ci）；协变量包括已知的混杂因素，即体重指数（BMI）、饮食和其他生活方式因素。超重和肥胖个体比例最高的是NH单独类别，而NH/亚洲类别的比例最低。在56岁队列进入后的12年随访中，通过问卷调查和健康计划联系确定了2,072例事件病例。调整BMI前后，NH组的hr均高于NH/white组。在完全调整的模型中，NH/Asian类别的风险最高（HR=1.45; 95%CI: 1.27-1.65），其次是NH/other （HR=1.20; 95%CI: 1.03-1.39）、NH/Chinese/white （HR=1.19; 95%CI: 1.04-1.37）和NH单独（HR=1.19; 95%CI: 1.03-1.37）。与超重/肥胖人群相比，正常体重人群中亚洲混血增加的风险更为明显。这些发现表明，与已知的危险因素无关，NHs中的亚洲混血儿与2型糖尿病的高风险相关，并提示与种族相关的遗传因素在该疾病的发展中起作用。
Obesity and diabetes rates are high in Native Hawaiians (NH) who commonly have mixed ancestries. Persons of Asian ancestry experience a high risk of type 2 diabetes despite the relatively low body weight. We evaluated the impact of ethnic admixture on diabetes risk among NH in the Multiethnic Cohort (MEC). Based on self-reports, 11,521 eligible men and women were categorized into NH/white, NH/other, NH alone, NH/Asian, and the most common three ancestry admixture, NH/Chinese/white. Cox proportional hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with the NH/white category as the reference group; covariates included known confounders, i.e., body mass index (BMI), dietary and other life-style factors. The NH alone category had the highest proportion of overweight and obese individuals and the NH/Asian category the lowest proportion. During 12 years of follow-up after cohort entry at 56 years, 2,072 incident cases were ascertained through questionnaires and health plan linkages. All NH categories had higher HRs than the NH/white category before and after adjustment for BMI. In fully-adjusted models, the NH/Asian category showed the highest risk (HR=1.45; 95%CI: 1.27–1.65), followed by NH/other (HR=1.20; 95%CI: 1.03–1.39), NH/Chinese/white (HR=1.19; 95%CI: 1.04–1.37), and NH alone (HR=1.19; 95%CI: 1.03–1.37). The elevated risk by Asian admixture was more pronounced in normal weight than overweight/obese individuals. These findings indicate that Asian admixture in NHs is associated with higher risk for type 2 diabetes independent of known risk factors and suggest a role for ethnicity-related genetic factors in the development of this disease.
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影响因子：
120.7
作者：
Flegal, KM;Carroll, MD;Johnson, CL
通讯作者：
Johnson, CL
影响因子：
2.9
作者：
Brown, Daniel E.;Hampson, Sarah E.;Dubanoski, Joan P.;Murai, Amy Stone;Hillier, Teresa A.
通讯作者：
Hillier, Teresa A.
影响因子：
5.2
作者：
Ma RC;Chan JC
通讯作者：
Chan JC
影响因子：
9.8
作者：
Bryc K;Durand EY;Macpherson JM;Reich D;Mountain JL
通讯作者：
Mountain JL
影响因子：
3.2
作者：
Doo, Taisha;Morimoto, Yukiko;Steinbrecher, Astrid;Kolonel, Laurence N.;Maskarinec, Gertraud
通讯作者：
Maskarinec, Gertraud