In it together: Candida-bacterial oral biofilms and therapeutic strategies.
In it together: Candida-bacterial oral biofilms and therapeutic strategies.
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一起：念珠菌口腔生物膜和治疗策略。
DOI：
10.1111/1758-2229.13053
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发表时间：
2022-04
影响因子：
3.3
通讯作者：
Hwang G
中科院分区：
文献类型：
--
作者：
Hwang G
在自然环境或人体内，大多数微生物存在于附着在非生物和生物表面的复杂的多微生物生物膜中。这些微生物在生物膜定植和发育过程中与其他物种表现出共生、互惠、协同或拮抗的关系。这些多微生物相互作用是异质性的，复杂的，难以控制的，因此往往产生比单种感染更糟糕的结果。关于真菌，特别是念珠菌，白色念珠菌经常与口腔生物膜中的各种细菌一起检测到。这些念珠菌与细菌的相互作用可能诱导白色念珠菌从共生菌转变为病原菌或益生菌。因此，念珠菌-细菌相互作用在很大程度上与各种口腔疾病有关，包括假牙口炎、龋齿、牙周炎、种植周炎、牙髓感染和口腔癌。考虑到由形成难以去除和高度耐药生物膜的跨界菌群引起的口腔疾病的严重性，有必要进行基础研究，战略性地开发具有成本效益和安全的疗法，以预防和治疗跨界相互作用和随后的生物膜形成。虽然研究已经揭示了一些光明，针对真菌涉及的多微生物生物膜是有限的。这篇迷你综述概述了念珠菌-细菌相互作用的主要特征及其对各种口腔疾病的影响。此外，目前的知识治疗策略，针对念珠菌细菌多微生物生物膜进行了讨论。
Under natural environmental settings or in the human body, the majority of microorganisms exist in complex polymicrobial biofilms adhered to abiotic and biotic surfaces. These microorganisms exhibit symbiotic, mutualistic, synergistic, or antagonistic relationships with other species during biofilm colonization and development. These polymicrobial interactions are heterogeneous, complex, and hard to control, thereby often yielding worse outcomes than monospecies infections. Concerning fungi, Candida spp., in particular, Candida albicans is often detected with various bacterial species in oral biofilms. These Candida-bacterial interactions may induce the transition of C. albicans from commensal to pathobiont or dysbiotic organism. Consequently, Candida–bacterial interactions are largely associated with various oral diseases, including denture stomatitis, dental caries, periodontitis, peri-implantitis, endodontic infections, and oral cancer. Given the severity of oral diseases caused by cross-kingdom consortia that develop hard-to-remove and highly drug-resistant biofilms, fundamental research is warranted to strategically develop cost-effective and safe therapies to prevent and treat cross-kingdom interactions and subsequent biofilm development. While studies have shed some light, targeting fungal-involved polymicrobial biofilms has been limited. This mini-review outlines the key features of Candida-bacterial interactions and their impact on various oral diseases. In addition, current knowledge on therapeutic strategies to target Candida-bacterial polymicrobial biofilms is discussed.
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DOI：
10.1590/1678-77572016-0021
发表时间：
2017-01
期刊：
Journal of applied oral science : revista FOB
影响因子：
--
作者：
Charone S;Portela MB;Martins KO;Soares RM;Castro GF
通讯作者：
Castro GF
DOI：
10.1073/pnas.95.13.7670
发表时间：
1998-06-23
影响因子：
11.1
作者：
Buurman, ET;Westwater, C;Gow, NAR
通讯作者：
Gow, NAR
影响因子：
3.1
作者：
Bombarda, Gabriela F.;Rosalen, Pedro L.;Sardi, Janaina C. O.
通讯作者：
Sardi, Janaina C. O.
影响因子：
4.2
作者：
Cavazana, Thamires Priscila;Pessan, Juliano Pelim;Botazzo Delbem, Alberto Carlos
通讯作者：
Botazzo Delbem, Alberto Carlos
影响因子：
2
作者：
Canullo, Luigi;Penarrocha-Oltra, David;Orlato Rossetti, Paulo Henrique
通讯作者：
Orlato Rossetti, Paulo Henrique