Leg Fidgeting During Prolonged Sitting Improves Postprandial Glycemic Control in People with Obesity.
Leg Fidgeting During Prolonged Sitting Improves Postprandial Glycemic Control in People with Obesity.
复制标题
DOI：
10.1002/oby.23173
复制
发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Kanaley JA
中科院分区：
文献类型：
--
作者：
Pettit-Mee RJ;Ready ST;Padilla J;Kanaley JA
研究表明，坐立不安会增加代谢需求，增加运动肢体的血流量，而久坐会抑制这些因素，并加剧餐后血糖波动。因此，我们假设长时间坐着时腿部坐立不安会改善餐后血糖控制。肥胖成人 (n=20) 参加了一项随机交叉试验，在摄入葡萄糖负荷 (75g) 后的 3 小时静坐期间测量血糖和胰岛素浓度。坐着时，受试者要么保持静止，要么间歇性地坐立不安双腿（休息 2.5 分钟/打开 2.5 分钟）。在坐姿期间还测量了加速度计计数、耗氧量和腘动脉血流量。正如预期的那样，坐立不安会增加加速度计计数（P<0.01）、耗氧量（P<0.01）和腘动脉血流量（P<0.05）。值得注意的是，坐立不安会降低葡萄糖（P<0.01）和胰岛素（P<0.05）曲线下总面积（AUC）和葡萄糖增量AUC（P<0.05）。此外，坐立不安引起的血流量增加与餐后第一小时内血糖 AUC 降低之间存在很强的负相关关系（r=-0.569，P<0.01）。腿部坐立不安是一种简单的低强度身体活动，可以增强肢体血流量，并且可以在长时间坐着时进行，以改善肥胖人群的餐后血糖控制。
Studies show fidgeting augments metabolic demand and increases blood flow to the moving limbs, whereas prolonged sitting suppresses these factors and exacerbates postprandial glucose excursions. Thus, we hypothesized that leg fidgeting during prolonged sitting would improve postprandial glycemic control. Adults with obesity (n=20) participated in a randomized, crossover trial in which blood glucose and insulin concentrations were measured during a 3-h sitting period following the ingestion of a glucose load (75g). During sitting, subjects either remained stationary or intermittently fidgeted both legs (2.5 minutes off/2.5 minutes on). Accelerometer counts, oxygen consumption, and popliteal artery blood flow were also measured during the sitting period. As expected, fidgeting increased accelerometer counts (P<0.01), oxygen consumption (P<0.01), and blood flow through the popliteal artery (P<0.05). Notably, fidgeting lowered both glucose (P<0.01) and insulin (P<0.05) total area under the curve (AUC) and glucose incremental AUC (P<0.05). Additionally, there was a strong, negative correlation between fidgeting-induced increases in blood flow and reduced postprandial glucose AUC within the first hour (r=−0.569, P<0.01). Leg fidgeting is a simple light-intensity physical activity that enhances limb blood flow and can be incorporated during prolonged sitting to improve postprandial glycemic control in people with obesity.
登录
查看更多内容
影响因子：
16.2
作者：
Dunstan DW;Kingwell BA;Larsen R;Healy GN;Cerin E;Hamilton MT;Shaw JE;Bertovic DA;Zimmet PZ;Salmon J;Owen N
通讯作者：
Owen N
DOI：
10.1152/ajpendo.1995.269.3.e583
发表时间：
1995-09-01
影响因子：
5.1
作者：
MARTIN, IK;KATZ, A;WAHREN, J
通讯作者：
WAHREN, J
影响因子：
16.2
作者：
Dempsey, Paddy C.;Larsen, Robyn N.;Dunstan, David W.
通讯作者：
Dunstan, David W.
影响因子：
6.9
作者：
Carroll, Joan F.;Kaiser, Kathryn A.;Caffrey, James L.
通讯作者：
Caffrey, James L.
影响因子：
5
作者：
Patel, Alpa V.;Bernstein, Leslie;Thun, Michael J.
通讯作者：
Thun, Michael J.